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Efficiency and sustainability in cyclizine synthesis: a comparative analysis of reductive amination methodologies

Egor A Cherezov 1
Egor A Cherezov
, 
Fedor S Kliuev 1, 2
Fedor S Kliuev
, 
Denis Alexandrovich Chusov 1, 2
Denis Alexandrovich Chusov
10.71267/mencom.7990
Published 28 July 2026 , received 24 December 2025
Communication , Volume 36, Issue 5, 563-564
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Cherezov E. A., Kliuev F. S., Chusov D. A. Efficiency and sustainability in cyclizine synthesis: a comparative analysis of reductive amination methodologies // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 563-564.
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Cherezov E. A., Kliuev F. S., Chusov D. A. Efficiency and sustainability in cyclizine synthesis: a comparative analysis of reductive amination methodologies // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 563-564.
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TY - JOUR
DO - 10.71267/mencom.7990
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7990
TI - Efficiency and sustainability in cyclizine synthesis: a comparative analysis of reductive amination methodologies
T2 - Mendeleev Communications
AU - Cherezov, Egor A
AU - Kliuev, Fedor S
AU - Chusov, Denis Alexandrovich
PY - 2026
DA - 2026/07/28
PB - Mendeleev Communications
SP - 563-564
IS - 5
VL - 36
ER -
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@article{2026_Cherezov,
author = {Egor A Cherezov and Fedor S Kliuev and Denis Alexandrovich Chusov},
title = {Efficiency and sustainability in cyclizine synthesis: a comparative analysis of reductive amination methodologies},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7990},
number = {5},
pages = {563--564},
doi = {10.71267/mencom.7990}
}
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Cherezov, Egor A., et al. “Efficiency and sustainability in cyclizine synthesis: a comparative analysis of reductive amination methodologies.” Mendeleev Communications, vol. 36, no. 5, Jul. 2026, pp. 563-564. https://mendcomm.colab.ws/publications/10.71267/mencom.7990.
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Keywords

active pharmaceutical ingredient
amine synthesis
cyclizine
formalin
green metrics
reductive amination

Abstract

A comparative study of cyclizine synthesis methods using reductive amination reactions is reported. Among them there are procedures involving hydride reagents [NaBH4, NaBH3CN, NaBH(OAc)3], hydrogenation over Pd/C and external reductant-free method using formalin only. The methods are also characterized using green chemistry metrics.

Funders

Russian Science Foundation
25-13-00085
Ministry of Education and Science of the Russian Federation
075-00276-25-00

References

2.
Mechanochemical Conversion of Aromatic Amines to Aryl Trifluoromethyl Ethers
Jakubczyk M., Mkrtchyan S., Shkoor M., Lanka S., Budzák Š., Iliaš M., Skoršepa M., Iaroshenko V.O.
Journal of the American Chemical Society, 2022
3.
ref-10.71267-mendc7489-1-11-1-0
4.
Reductive Amination in the Synthesis of Pharmaceuticals.
Afanasyev O.I., Kuchuk E., Usanov D.L., Chusov D.
Chemical Reviews, 2019
5.
Hitchhiker’s Guide to Reductive Amination
Podyacheva E., Afanasyev O.I., Tsygankov A.A., Makarova M., Chusov D.
Synthesis, 2019
6.
The green chemistry paradigm in modern organic synthesis
Zlotin Sergei G., Egorova Ksenia S., Ananikov Valentine P., Akulov Alexey A., Varaksin Mikhail V., Chupakhin Oleg N., Charushin Valery N., Bryliakov Konstantin P., Averin Alexey D., Beletskaya Irina P., Dolengovski Egor L., Budnikova Yulia H., Sinyashin Oleg G., Gafurov Zufar N., Kantyukov Artyom O., et. al.
Russian Chemical Reviews, 2024