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Synthesis of a pteroic-based conjugate with ibuprofen moiety and macrocyclic chelator DOTA-GA

Natalya Sergeevna Volkova 1
Natalya Sergeevna Volkova
, 
Anton A. Larenkov 2
Anton A. Larenkov
, 
Nina S. Boutakova 1
Nina S. Boutakova
, 
Elena Kimovna Beloglazkina 1
Elena Kimovna Beloglazkina
, 
2 Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123098 Moscow, Russian Federation
10.71267/mencom.7764
Published 2025-10-21
Communication , Volume 35, Issue 6, 670-672
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Volkova N. S. et al. Synthesis of a pteroic-based conjugate with ibuprofen moiety and macrocyclic chelator DOTA-GA // Mendeleev Communications. 2025. Vol. 35. No. 6. pp. 670-672.
GOST all authors (up to 50) Copy
Volkova N. S., Larenkov A. A., Boutakova N. S., Beloglazkina E. K., Machulkin A. E. Synthesis of a pteroic-based conjugate with ibuprofen moiety and macrocyclic chelator DOTA-GA // Mendeleev Communications. 2025. Vol. 35. No. 6. pp. 670-672.
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TY - JOUR
DO - 10.71267/mencom.7764
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7764
TI - Synthesis of a pteroic-based conjugate with ibuprofen moiety and macrocyclic chelator DOTA-GA
T2 - Mendeleev Communications
AU - Volkova, Natalya Sergeevna
AU - Larenkov, Anton A.
AU - Boutakova, Nina S.
AU - Beloglazkina, Elena Kimovna
AU - Machulkin, Aleksei Eduardovich
PY - 2025
DA - 2025/10/21
PB - Mendeleev Communications
SP - 670-672
IS - 6
VL - 35
ER -
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@article{2025_Volkova,
author = {Natalya Sergeevna Volkova and Anton A. Larenkov and Nina S. Boutakova and Elena Kimovna Beloglazkina and Aleksei Eduardovich Machulkin},
title = {Synthesis of a pteroic-based conjugate with ibuprofen moiety and macrocyclic chelator DOTA-GA},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7764},
number = {6},
pages = {670--672},
doi = {10.71267/mencom.7764}
}
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Volkova, Natalya Sergeevna, et al. “Synthesis of a pteroic-based conjugate with ibuprofen moiety and macrocyclic chelator DOTA-GA.” Mendeleev Communications, vol. 35, no. 6, Oct. 2025, pp. 670-672. https://mendcomm.colab.ws/publications/10.71267/mencom.7764.

Keywords

conjugates
delivery
DOTA-GA.
folate receptors
peptide
peptide synthesis
pteroic acid

Abstract

Conjugate containing fragments of pteroic acid, anti-inflammatory drug ibuprofen, macrocyclic chelator DOTA-GA and (His-Glu)2 moiety has been synthesized. Key structural motifs of this compound were introduced to optimize the pharmacokinetic characteristics of the pteroic acid-based conjugate. The complexation of the conjugate with radioactive lutetium-177 provided radiochemical yield of >99% and radiochemical purity of 97.6%.

Funders

Russian Science Foundation
22-15-00098-P