Home / Publications / Molecular weight of polyanion affects the biological activity of interpolycomplexes

Molecular weight of polyanion affects the biological activity of interpolycomplexes

, 
Arina Yu Rosova 2
Arina Yu Rosova
,  , 
Nataliya G Loiko 3
Nataliya G Loiko
, 
Yuriy Alexandrovich Nikolaev 3
Yuriy Alexandrovich Nikolaev
, 
Aleksandr Anatol'evich Yaroslavov 1
Aleksandr Anatol'evich Yaroslavov
1 Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
2 M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation
3 Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow, Russian Federation
10.1016/j.mencom.2024.01.029
Published 2023-12-25
Communication , Volume 34, Issue 1, 97-99
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Lokova A. Y. et al. Molecular weight of polyanion affects the biological activity of interpolycomplexes // Mendeleev Communications. 2023. Vol. 34. No. 1. pp. 97-99.
GOST all authors (up to 50) Copy
Lokova A. Y., Rosova A. Yu., Panova I. G., Loiko N. G., Nikolaev Y. A., Yaroslavov A. A. Molecular weight of polyanion affects the biological activity of interpolycomplexes // Mendeleev Communications. 2023. Vol. 34. No. 1. pp. 97-99.
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TY - JOUR
DO - 10.1016/j.mencom.2024.01.029
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.01.029
TI - Molecular weight of polyanion affects the biological activity of interpolycomplexes
T2 - Mendeleev Communications
AU - Lokova, Anastasia Yurievna
AU - Rosova, Arina Yu
AU - Panova, Irina Gennadievna
AU - Loiko, Nataliya G
AU - Nikolaev, Yuriy Alexandrovich
AU - Yaroslavov, Aleksandr Anatol'evich
PY - 2023
DA - 2023/12/25
PB - Mendeleev Communications
SP - 97-99
IS - 1
VL - 34
ER -
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@article{2023_Lokova,
author = {Anastasia Yurievna Lokova and Arina Yu Rosova and Irina Gennadievna Panova and Nataliya G Loiko and Yuriy Alexandrovich Nikolaev and Aleksandr Anatol'evich Yaroslavov},
title = {Molecular weight of polyanion affects the biological activity of interpolycomplexes},
journal = {Mendeleev Communications},
year = {2023},
volume = {34},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.01.029},
number = {1},
pages = {97--99},
doi = {10.1016/j.mencom.2024.01.029}
}
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Lokova, Anastasia Yurievna, et al. “Molecular weight of polyanion affects the biological activity of interpolycomplexes.” Mendeleev Communications, vol. 34, no. 1, Dec. 2023, pp. 97-99. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.01.029.
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Keywords

antimicrobial activity.
complexation
liposomes
polyanion
polycation
polycomplex

Abstract

Cationic poly(diallyldimethylammonium chloride) forms nonstoichiometric positively charged interpolyelectrolyte complexes (IPECs) with short- and long-chain anionic sodium polyacrylate. When added to anionic liposomes, the short-chain polyanion IPECs dissociate and the free polycation binds to the liposomes, whereas the long-chain polyanion IPECs bind to the liposomes as a whole. These results correlate with the antimicrobial activity of IPECs, thereby highlighting the important role of polymer molecular weight in the cellular response to IPEC binding.

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