Home / Publications / Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation

Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation

, 
Sergey Valeryevich Kositov 1
Sergey Valeryevich Kositov
, 
Denis Vadimovich Zverev 1
Denis Vadimovich Zverev
, 
Eugene V Radchenko 1
Eugene V Radchenko
,  , 
Alexey Vital'evich Gabrel'yan 2
Alexey Vital'evich Gabrel'yan
, 
Vladimir Lollievich Zamoyski 2
Vladimir Lollievich Zamoyski
, 
Vladimir Viktorovich Grigoriev 1, 2
Vladimir Viktorovich Grigoriev
, 
Elena Borisovna Averina 1
Elena Borisovna Averina
, 
Vladimir Alexandrovich Palyulin 1
Vladimir Alexandrovich Palyulin
1 Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
2 Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
10.1016/j.mencom.2024.01.002
Published 2023-12-25
Communication , Volume 34, Issue 1, 8-10
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Sedenkova K. N. et al. Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation // Mendeleev Communications. 2023. Vol. 34. No. 1. pp. 8-10.
GOST all authors (up to 50) Copy
Sedenkova K. N., Kositov S. V., Zverev D. V., Radchenko E. V., Grishin Y. K., Gabrel'yan A. V., Zamoyski V. L., Grigoriev V. V., Averina E. B., Palyulin V. A. Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation // Mendeleev Communications. 2023. Vol. 34. No. 1. pp. 8-10.
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TY - JOUR
DO - 10.1016/j.mencom.2024.01.002
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.01.002
TI - Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation
T2 - Mendeleev Communications
AU - Sedenkova, Kseniya N
AU - Kositov, Sergey Valeryevich
AU - Zverev, Denis Vadimovich
AU - Radchenko, Eugene V
AU - Grishin, Yuri Konstantinovich
AU - Gabrel'yan, Alexey Vital'evich
AU - Zamoyski, Vladimir Lollievich
AU - Grigoriev, Vladimir Viktorovich
AU - Averina, Elena Borisovna
AU - Palyulin, Vladimir Alexandrovich
PY - 2023
DA - 2023/12/25
PB - Mendeleev Communications
SP - 8-10
IS - 1
VL - 34
ER -
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@article{2023_Sedenkova,
author = {Kseniya N Sedenkova and Sergey Valeryevich Kositov and Denis Vadimovich Zverev and Eugene V Radchenko and Yuri Konstantinovich Grishin and Alexey Vital'evich Gabrel'yan and Vladimir Lollievich Zamoyski and Vladimir Viktorovich Grigoriev and Elena Borisovna Averina and Vladimir Alexandrovich Palyulin},
title = {Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation},
journal = {Mendeleev Communications},
year = {2023},
volume = {34},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.01.002},
number = {1},
pages = {8--10},
doi = {10.1016/j.mencom.2024.01.002}
}
MLA
Cite this
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Sedenkova, Kseniya N., et al. “Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation.” Mendeleev Communications, vol. 34, no. 1, Dec. 2023, pp. 8-10. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.01.002.
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Keywords

allosteric modulators
AMPA receptor
aromatic nucleophilic substitution
bivalent ligands.
pyrimidines

Abstract

A series of new bis(pyrimidines) with p-hydroquinone linker was prepared and evaluated as AMPA receptor modulators. Both positive and negative modulators were found among the investigated compounds.

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