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Thermosensitive and mucoadhesive hydrogels based on modified alginate as drug carriers

Marina Yur`evna Gorshkova 1
Marina Yur`evna Gorshkova
, 
Ludmila Vital'evna Vanchugova 1
Ludmila Vital'evna Vanchugova
, 
Irina Fedorovna Volkova 1
Irina Fedorovna Volkova
, 
Irina Vasil'evna Obydennova 1
Irina Vasil'evna Obydennova
, 
Ivan L'vovich Valuev 1
Ivan L'vovich Valuev
, 
Lev Ivanovich Valuev 1
Lev Ivanovich Valuev
1 A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russian Federation
10.1016/j.mencom.2023.10.020
Published 2023-10-18
Communication , Volume 33, Issue 6, 799-801
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Gorshkova M. Y. et al. Thermosensitive and mucoadhesive hydrogels based on modified alginate as drug carriers // Mendeleev Communications. 2023. Vol. 33. No. 6. pp. 799-801.
GOST all authors (up to 50) Copy
Gorshkova M. Y., Vanchugova L. V., Volkova I. F., Obydennova I. V., Valuev I. L., Valuev L. I. Thermosensitive and mucoadhesive hydrogels based on modified alginate as drug carriers // Mendeleev Communications. 2023. Vol. 33. No. 6. pp. 799-801.
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TY - JOUR
DO - 10.1016/j.mencom.2023.10.020
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.10.020
TI - Thermosensitive and mucoadhesive hydrogels based on modified alginate as drug carriers
T2 - Mendeleev Communications
AU - Gorshkova, Marina Yur`evna
AU - Vanchugova, Ludmila Vital'evna
AU - Volkova, Irina Fedorovna
AU - Obydennova, Irina Vasil'evna
AU - Valuev, Ivan L'vovich
AU - Valuev, Lev Ivanovich
PY - 2023
DA - 2023/10/18
PB - Mendeleev Communications
SP - 799-801
IS - 6
VL - 33
ER -
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@article{2023_Gorshkova,
author = {Marina Yur`evna Gorshkova and Ludmila Vital'evna Vanchugova and Irina Fedorovna Volkova and Irina Vasil'evna Obydennova and Ivan L'vovich Valuev and Lev Ivanovich Valuev},
title = {Thermosensitive and mucoadhesive hydrogels based on modified alginate as drug carriers},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.10.020},
number = {6},
pages = {799--801},
doi = {10.1016/j.mencom.2023.10.020}
}
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Gorshkova, Marina Yur`evna, et al. “Thermosensitive and mucoadhesive hydrogels based on modified alginate as drug carriers.” Mendeleev Communications, vol. 33, no. 6, Oct. 2023, pp. 799-801. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.10.020.

Keywords

covalent network
drug delivery system.
interpenetrating networks
ionic network
N-diethylacrylamide)
poly(N
sodium alginate
thermosensitive hydrogel
two-component hydrogels
unsaturated derivatives

Abstract

New thermosensitive mucoadhesive hydrogels based on a sodium alginate unsaturated derivative have been synthesized by copolymerization with N,N-diethylacrylamide (DEAAm) in the presence of a crosslinking agent. The formation of covalent bonds between the co-monomers has been shown to cause a significant change in the hydrogel supramolecular structure and makes it possible to regulate the lower critical solution temperature (LCST) of the gels. The possibility of using the hydrogels as drug carriers with a temperature- controlled drug release rate has been demonstrated in experiments in vitro

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