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A convenient synthesis of new phosphonomethyl-containing 4,5-dihydropyridazin-3(2H)-ones

Oumayma Bejaoui 1, 2
Oumayma Bejaoui
, 
Abderrahmen Abdelli 1
Abderrahmen Abdelli
, 
Hedi M'rabet 1
Hedi M'rabet
, 
Xavier Moreau 2
Xavier Moreau
, 
Mohamed Lotfi Efrit 1
Mohamed Lotfi Efrit
, 
Damien Prim 2
Damien Prim
1 Department of Chemistry, Faculty of Sciences, University of Tunis El Manar, Tunis, Tunisia
2 Institut Lavoisier de Versailles, Versailles, France
10.1016/j.mencom.2023.09.016
Published 2023-09-01
Communication , Volume 33, Issue 5, 640-641
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Bejaoui O. et al. A convenient synthesis of new phosphonomethyl-containing 4,5-dihydropyridazin-3(2H)-ones // Mendeleev Communications. 2023. Vol. 33. No. 5. pp. 640-641.
GOST all authors (up to 50) Copy
Bejaoui O., Abdelli A., M'rabet H., Moreau X., Efrit M. L., Prim D. A convenient synthesis of new phosphonomethyl-containing 4,5-dihydropyridazin-3(2H)-ones // Mendeleev Communications. 2023. Vol. 33. No. 5. pp. 640-641.
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TY - JOUR
DO - 10.1016/j.mencom.2023.09.016
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.09.016
TI - A convenient synthesis of new phosphonomethyl-containing 4,5-dihydropyridazin-3(2H)-ones
T2 - Mendeleev Communications
AU - Bejaoui, Oumayma
AU - Abdelli, Abderrahmen
AU - M'rabet, Hedi
AU - Moreau, Xavier
AU - Efrit, Mohamed Lotfi
AU - Prim, Damien
PY - 2023
DA - 2023/09/01
PB - Mendeleev Communications
SP - 640-641
IS - 5
VL - 33
ER -
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@article{2023_Bejaoui,
author = {Oumayma Bejaoui and Abderrahmen Abdelli and Hedi M'rabet and Xavier Moreau and Mohamed Lotfi Efrit and Damien Prim},
title = {A convenient synthesis of new phosphonomethyl-containing 4,5-dihydropyridazin-3(2H)-ones},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.09.016},
number = {5},
pages = {640--641},
doi = {10.1016/j.mencom.2023.09.016}
}
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Bejaoui, Oumayma, et al. “A convenient synthesis of new phosphonomethyl-containing 4,5-dihydropyridazin-3(2H)-ones.” Mendeleev Communications, vol. 33, no. 5, Sep. 2023, pp. 640-641. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.09.016.

Keywords

Michael addition
Nef reaction.
nitroalkanes
phosphonates
pyridazin-3(2H)-ones
γ-keto ester

Abstract

An expedient access to novel 4-phosphonomethyl-containing 2,6-disubstituted 4,5-dihydropyridazin-3(2H)-ones involves the reaction of β-phosphono γ'-keto ester intermediates with hydrazines. The construction of the pyridazinone ring allows the installation of various substituents at the positions 2 and 6 as well as a valuable 4-positioned phosphonomethyl fragment.

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