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Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies

Giang V Nguyen 1
Giang V Nguyen
, 
Hoang T Dang 1
Hoang T Dang
, 
Luyen D Nguyen 1
Luyen D Nguyen
, 
Hai V Nguyen 1
Hai V Nguyen
, 
Huong T Le 1
Huong T Le
, 
Huy H.N Nguyen 2
Huy H.N Nguyen
, 
An V Nguyen 2
An V Nguyen
, 
Yen H Nguyen 3
Yen H Nguyen
, 
Van-Ha Nguyen 3
Van-Ha Nguyen
, 
Huy-Hoang Do 3
Huy-Hoang Do
1 Hanoi University of Pharmacy, Phan Chu Trinh, Hoan Kiem, Hanoi, Vietnam
2 Nguyen Gia Thieu High School, Long Bien, Gia Lam, Hanoi, Vietnam
3 Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Hoan Kiem, Hanoi, Vietnam
10.1016/j.mencom.2023.06.033
Published 2023-06-13
Communication , Volume 33, Issue 4, 543-545
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Nguyen G. V. et al. Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 543-545.
GOST all authors (up to 50) Copy
Nguyen G. V., Dang H. T., Nguyen L. D., Nguyen H. V., Le H. T., Nguyen H. H., Nguyen A. V., Nguyen Y. H., Nguyen V., Do H. Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 543-545.
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TY - JOUR
DO - 10.1016/j.mencom.2023.06.033
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.06.033
TI - Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies
T2 - Mendeleev Communications
AU - Nguyen, Giang V
AU - Dang, Hoang T
AU - Nguyen, Luyen D
AU - Nguyen, Hai V
AU - Le, Huong T
AU - Nguyen, Huy H.N
AU - Nguyen, An V
AU - Nguyen, Yen H
AU - Nguyen, Van-Ha
AU - Do, Huy-Hoang
PY - 2023
DA - 2023/06/13
PB - Mendeleev Communications
SP - 543-545
IS - 4
VL - 33
ER -
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@article{2023_Nguyen,
author = {Giang V Nguyen and Hoang T Dang and Luyen D Nguyen and Hai V Nguyen and Huong T Le and Huy H.N Nguyen and An V Nguyen and Yen H Nguyen and Van-Ha Nguyen and Huy-Hoang Do},
title = {Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.06.033},
number = {4},
pages = {543--545},
doi = {10.1016/j.mencom.2023.06.033}
}
MLA
Cite this
MLA Copy
Nguyen, Giang V., et al. “Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies.” Mendeleev Communications, vol. 33, no. 4, Jun. 2023, pp. 543-545. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.06.033.

Keywords

arylidene indolones
enzyme docking
indolones
sulfonamides
α-glucosidase inhibitor

Abstract

3-Arylidene-1-(2,6-dichlorophenyl)indolones and in particular their 5-methylaminosulfonyl derivatives efficiently inhibit α-glucosidase enzyme. The results are corroborated by in silico docking studies which show the binding of aminosulfonyl derivatives to be more favorable due to additional hydrogen bonding. The most active compound of the series shows the IC50 of 6.19 μm.

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