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Synthesis of 1-oxa-9-azaspiro[5.5]undecane-9-sulfonamides bearing a diverse molecular periphery and a rare zinc-binding group for carbonic anhydrase interrogation

Alexei Yur'evich Lukin 1
Alexei Yur'evich Lukin
, 
Lyubov V Vinogradova 1
Lyubov V Vinogradova
, 
Kristina Yuryevna Komarova 1
Kristina Yuryevna Komarova
, 
Stanislav Alekseevich Kalinin 2
Stanislav Alekseevich Kalinin
, 
Mikhail Yur'evich Krasavin 2, 3
Mikhail Yur'evich Krasavin
1 M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation
2 Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
3 Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation
10.1016/j.mencom.2023.02.013
Published 2023-02-13
Communication , Volume 33, Issue 2, 191-193
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Lukin A. Y. et al. Synthesis of 1-oxa-9-azaspiro[5.5]undecane-9-sulfonamides bearing a diverse molecular periphery and a rare zinc-binding group for carbonic anhydrase interrogation // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 191-193.
GOST all authors (up to 50) Copy
Lukin A. Y., Vinogradova L. V., Komarova K. Y., Kalinin S. A., Krasavin M. Y. Synthesis of 1-oxa-9-azaspiro[5.5]undecane-9-sulfonamides bearing a diverse molecular periphery and a rare zinc-binding group for carbonic anhydrase interrogation // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 191-193.
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TY - JOUR
DO - 10.1016/j.mencom.2023.02.013
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.013
TI - Synthesis of 1-oxa-9-azaspiro[5.5]undecane-9-sulfonamides bearing a diverse molecular periphery and a rare zinc-binding group for carbonic anhydrase interrogation
T2 - Mendeleev Communications
AU - Lukin, Alexei Yur'evich
AU - Vinogradova, Lyubov V
AU - Komarova, Kristina Yuryevna
AU - Kalinin, Stanislav Alekseevich
AU - Krasavin, Mikhail Yur'evich
PY - 2023
DA - 2023/02/13
PB - Mendeleev Communications
SP - 191-193
IS - 2
VL - 33
ER -
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@article{2023_Lukin,
author = {Alexei Yur'evich Lukin and Lyubov V Vinogradova and Kristina Yuryevna Komarova and Stanislav Alekseevich Kalinin and Mikhail Yur'evich Krasavin},
title = {Synthesis of 1-oxa-9-azaspiro[5.5]undecane-9-sulfonamides bearing a diverse molecular periphery and a rare zinc-binding group for carbonic anhydrase interrogation},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.013},
number = {2},
pages = {191--193},
doi = {10.1016/j.mencom.2023.02.013}
}
MLA
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Lukin, Alexei Yur'evich, et al. “Synthesis of 1-oxa-9-azaspiro[5.5]undecane-9-sulfonamides bearing a diverse molecular periphery and a rare zinc-binding group for carbonic anhydrase interrogation.” Mendeleev Communications, vol. 33, no. 2, Feb. 2023, pp. 191-193. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.013.

Keywords

1-oxa-9-azaspiro[5.5]undecanes
carbonic anhydrases
chemical diversity
druglikeness.
spiro compounds
sulfamide zinc binding group

Abstract

A fundamentally novel type of molecular probes for the recognition by carbonic anhydrase zinc enzymes which constitute promising target family in diverse therapeutic areas has been designed and synthesized. To the best of our knowledge, these molecular tools of 1-oxa-9-azaspiro[5.5]-undecane-9-sulfonamide chemotype for the first time combine in their structure diversely substituted spirocyclic piperidines and an aminosulfamoyl moiety.

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