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Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines

Dmitry Aleksandrovich Khochenkov 1, 2
Dmitry Aleksandrovich Khochenkov
, 
Yulia A Khochenkova 2
Yulia A Khochenkova
, 
Yulia S Machkova 2
Yulia S Machkova
, 
Rovshan E Gasanov 1
Rovshan E Gasanov
, 
Eugenia V Stepanova 2
Eugenia V Stepanova
, 
Alexander Siyasatovich Bunev 1
Alexander Siyasatovich Bunev
10.1016/j.mencom.2020.09.017
Published 2020-08-31
Communication , Volume 30, Issue 5, 604-606
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Khochenkov D. A. et al. Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines // Mendeleev Communications. 2020. Vol. 30. No. 5. pp. 604-606.
GOST all authors (up to 50) Copy
Khochenkov D. A., Khochenkova Y. A., Machkova Y. S., Gasanov R. E., Stepanova E. V., Bunev A. S. Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines // Mendeleev Communications. 2020. Vol. 30. No. 5. pp. 604-606.
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TY - JOUR
DO - 10.1016/j.mencom.2020.09.017
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.09.017
TI - Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines
T2 - Mendeleev Communications
AU - Khochenkov, Dmitry Aleksandrovich
AU - Khochenkova, Yulia A
AU - Machkova, Yulia S
AU - Gasanov, Rovshan E
AU - Stepanova, Eugenia V
AU - Bunev, Alexander Siyasatovich
PY - 2020
DA - 2020/08/31
PB - Mendeleev Communications
SP - 604-606
IS - 5
VL - 30
ER -
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@article{2020_Khochenkov,
author = {Dmitry Aleksandrovich Khochenkov and Yulia A Khochenkova and Yulia S Machkova and Rovshan E Gasanov and Eugenia V Stepanova and Alexander Siyasatovich Bunev},
title = {Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Aug},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.09.017},
number = {5},
pages = {604--606},
doi = {10.1016/j.mencom.2020.09.017}
}
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Khochenkov, Dmitry Aleksandrovich, et al. “Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines.” Mendeleev Communications, vol. 30, no. 5, Aug. 2020, pp. 604-606. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.09.017.

Keywords

cancer cell lines
cytotoxic activity
heterocyclization
isothiouronic salts
nitriles
pyrimidines
sulfones

Abstract

Novel 4-amino-5-cyano-2-sulfonylpyrimidines were prepared based on three-component cyclization between isothiouronium salts, benzaldehydes and malononitrile, followed by oxidation of the sulfide moiety with Oxone. The cytotoxic activity of the synthesized compounds, as well as the induction of apoptosis, inhibition of the cell cycle and proliferation tests were performed on selected cancer cell lines A431, A549, A375, HCT 116, MCF7, LNCap and SH-SY5Y.

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