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A convenient synthesis of new (1,2,4-triazolylamino)pyrimidines from cyanamide precursor

Mikhail Avramovich Prezent 1
Mikhail Avramovich Prezent
, 
Sergey Viktorovich Baranin 1
Sergey Viktorovich Baranin
, 
Yurii Nikolaevich Bubnov 1
Yurii Nikolaevich Bubnov
10.1016/j.mencom.2020.07.032
Published 2020-06-26
Communication , Volume 30, Issue 4, 500-501
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Prezent M. A., Baranin S. V., Bubnov Y. N. A convenient synthesis of new (1,2,4-triazolylamino)pyrimidines from cyanamide precursor // Mendeleev Communications. 2020. Vol. 30. No. 4. pp. 500-501.
GOST all authors (up to 50) Copy
Prezent M. A., Baranin S. V., Bubnov Y. N. A convenient synthesis of new (1,2,4-triazolylamino)pyrimidines from cyanamide precursor // Mendeleev Communications. 2020. Vol. 30. No. 4. pp. 500-501.
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TY - JOUR
DO - 10.1016/j.mencom.2020.07.032
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.07.032
TI - A convenient synthesis of new (1,2,4-triazolylamino)pyrimidines from cyanamide precursor
T2 - Mendeleev Communications
AU - Prezent, Mikhail Avramovich
AU - Baranin, Sergey Viktorovich
AU - Bubnov, Yurii Nikolaevich
PY - 2020
DA - 2020/06/26
PB - Mendeleev Communications
SP - 500-501
IS - 4
VL - 30
ER -
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@article{2020_Prezent,
author = {Mikhail Avramovich Prezent and Sergey Viktorovich Baranin and Yurii Nikolaevich Bubnov},
title = {A convenient synthesis of new (1,2,4-triazolylamino)pyrimidines from cyanamide precursor},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.07.032},
number = {4},
pages = {500--501},
doi = {10.1016/j.mencom.2020.07.032}
}
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Prezent, Mikhail Avramovich, et al. “A convenient synthesis of new (1,2,4-triazolylamino)pyrimidines from cyanamide precursor.” Mendeleev Communications, vol. 30, no. 4, Jun. 2020, pp. 500-501. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.07.032.

Keywords

1,2,4-triazoles
amino acids
Boc-deprotection
cyanamides
heterocyclization
hydrazides
piperazines
pyrimidines

Abstract

The Ni(acac)2-catalyzed 1,2,4-triazole formation from cyanamides and carbohydrazides was extended onto N-(4,6-dimethylpyrimidin-2-yl)cyanamide and glycine hydrazides. The obtained N-(5-aminomethyl-4H-1,2,4-triazol-3-yl)-4,6-dimethylpyrimidin-2-amines may be attractive for the estimation of their biological activity.

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