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Synthesis of new pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans

Margarita Alekseevna Epishina 1
Margarita Alekseevna Epishina
, 
Alexander Sergeyevich Kulikov 1
Alexander Sergeyevich Kulikov
,  , 
Ivan Vyacheslavovich Ananyev 2, 3
Ivan Vyacheslavovich Ananyev
, 
Nina Nikolaevna Makhova 1
Nina Nikolaevna Makhova
10.1016/j.mencom.2019.05.015
Published 2019-04-26
Communication , Volume 29, Issue 3, 288-291
8
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Epishina M. A. et al. Synthesis of new pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans // Mendeleev Communications. 2019. Vol. 29. No. 3. pp. 288-291.
GOST all authors (up to 50) Copy
Epishina M. A., Kulikov A. S., Fershtat L. L., Ananyev I. V., Makhova N. N. Synthesis of new pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans // Mendeleev Communications. 2019. Vol. 29. No. 3. pp. 288-291.
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TY - JOUR
DO - 10.1016/j.mencom.2019.05.015
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.05.015
TI - Synthesis of new pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans
T2 - Mendeleev Communications
AU - Epishina, Margarita Alekseevna
AU - Kulikov, Alexander Sergeyevich
AU - Fershtat, Leonid Leonidovich
AU - Ananyev, Ivan Vyacheslavovich
AU - Makhova, Nina Nikolaevna
PY - 2019
DA - 2019/04/26
PB - Mendeleev Communications
SP - 288-291
IS - 3
VL - 29
ER -
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@article{2019_Epishina,
author = {Margarita Alekseevna Epishina and Alexander Sergeyevich Kulikov and Leonid Leonidovich Fershtat and Ivan Vyacheslavovich Ananyev and Nina Nikolaevna Makhova},
title = {Synthesis of new pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.05.015},
number = {3},
pages = {288--291},
doi = {10.1016/j.mencom.2019.05.015}
}
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Epishina, Margarita Alekseevna, et al. “Synthesis of new pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans.” Mendeleev Communications, vol. 29, no. 3, Apr. 2019, pp. 288-291. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.05.015.

Abstract

The effective synthesis of pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans, comprising furoxan moiety as NO-donor and pharmacophoric pyrazolylthiazole fragment is based on the condensation of (2-hydrazinylthiazol-4-yl)furoxan hydrobromides with linear 1,3-diketones. The reaction proceeds through hydroxypyrazoline intermediate.

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