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Reduction of Schiff bases with sodium hypophosphite

Artemy Renatovich Fatkulin 1, 2
Artemy Renatovich Fatkulin
, 
Evgeniya S Podyacheva 1, 2
Evgeniya S Podyacheva
,  , 
Denis Alexandrovich Chusov 1, 2
Denis Alexandrovich Chusov
10.71267/mencom.8129
Published 23 September 2026
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Fatkulin A. R. et al. Reduction of Schiff bases with sodium hypophosphite // Mendeleev Communications. 2026.
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Fatkulin A. R., Podyacheva E. S., Afanasyev O. I., Chusov D. A. Reduction of Schiff bases with sodium hypophosphite // Mendeleev Communications. 2026.
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TY - JOUR
DO - 10.71267/mencom.8129
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8129
TI - Reduction of Schiff bases with sodium hypophosphite
T2 - Mendeleev Communications
AU - Fatkulin, Artemy Renatovich
AU - Podyacheva, Evgeniya S
AU - Afanasyev, Oleg Ilyich
AU - Chusov, Denis Alexandrovich
PY - 2026
DA - 2026/09/23
PB - Mendeleev Communications
ER -
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@article{2026_Fatkulin,
author = {Artemy Renatovich Fatkulin and Evgeniya S Podyacheva and Oleg Ilyich Afanasyev and Denis Alexandrovich Chusov},
title = {Reduction of Schiff bases with sodium hypophosphite},
journal = {Mendeleev Communications},
year = {2026},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8129},
doi = {10.71267/mencom.8129}
}
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Keywords

amines
catalyst-free
reduction
Schiff bases
sodium hypophosphite

Abstract

In this communication we report a convenient method for the preparation of amines via the catalyst-free reduction of Schiff bases with environment-friendly, cheap, and readily available sodium hypophosphite. The reaction is carried out at moderate heating (120 °C) in DMSO and can be performed on aromatic and aliphatic Schiff bases giving target amines in 36–91% yields.

Funders

Russian Science Foundation
24-73-00162
Ministry of Education and Science of the Russian Federation
075-00276-25-00