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Practical one-pot synthesis of N-alkyl-5-fluoropyrazoles

B. I. Ugrak 1
B. I. Ugrak
, 
T. Ya. Dutova 1
T. Ya. Dutova
,  , 
E. V. Tretyakov 1
E. V. Tretyakov
10.71267/mencom.8110
Published 5 November 2026 , received 8 June 2026
Communication
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Ugrak B. I. et al. Practical one-pot synthesis of N-alkyl-5-fluoropyrazoles // Mendeleev Communications. 2026.
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Ugrak B. I., Dutova T. Y., Tretyakov E. V., Tretyakov E. V. Practical one-pot synthesis of N-alkyl-5-fluoropyrazoles // Mendeleev Communications. 2026.
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TY - JOUR
DO - 10.71267/mencom.8110
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8110
TI - Practical one-pot synthesis of N-alkyl-5-fluoropyrazoles
T2 - Mendeleev Communications
AU - Ugrak, B. I.
AU - Dutova, T. Ya.
AU - Tretyakov, E. V.
AU - Tretyakov, E. V.
PY - 2026
DA - 2026/11/05
PB - Mendeleev Communications
ER -
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@article{2026_Ugrak,
author = {B. I. Ugrak and T. Ya. Dutova and E. V. Tretyakov and E. V. Tretyakov},
title = {Practical one-pot synthesis of N-alkyl-5-fluoropyrazoles},
journal = {Mendeleev Communications},
year = {2026},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8110},
doi = {10.71267/mencom.8110}
}
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Keywords

5-membered heterocycles
fluoropyrazoles
organofluorine compounds
perchloryl fluoride
pyrazoles

Abstract

Three N-alkyl-5-fluoropyrazoles were prepared from the corresponding N-alkylpyrazoles (60–64% yields) by lithiation (BuLi) at the 5-position followed by treatment with perchloryl fluoride (FClO3) in the same vessel. The obtained compounds can be regarded as versatile building blocks for the development of medicinal and agrochemical agents.

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