Keywords
bone substitute
collagen
fibroin
gelatin
mesenchymal cells
osteogenic differentiation
porous scaffolds
Abstract
Blending of natural polymers with synthetic calcium ceramics, followed by the subsequent preparation of porous scaffolds and seeding of mesenchymal stromal cells (MSCs), is a promising approach for fabricating effective materials for bone tissue regeneration. We prepared porous scaffolds comprising silk fibroin in combination with gelatin or collagen, and carbonated apatite via solution mixing and lyophilization. Seeded MSCs showed high values of cell proliferation and osteogenic differentiation; several three-component materials exceeded BioOss® xenograft in these parameters.
Funders
Russian Science Foundation
21-73-30010P
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