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Synthesis of new cationic porphyrin with targeting Dasatinib moiety

Yuliya Sergeevna Bortnevskaya 1
Yuliya Sergeevna Bortnevskaya
, 
Natalia Yu Karpechenko 1, 2, 3
Natalia Yu Karpechenko
, 
Natal'ya Aleksandrovna Bragina 1
Natal'ya Aleksandrovna Bragina
, 
Kseniya Aleksandrovna Zhdanova 1
Kseniya Aleksandrovna Zhdanova
10.71267/mencom.8088
Published 23 September 2026 , received 6 May 2026
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Bortnevskaya Y. S. et al. Synthesis of new cationic porphyrin with targeting Dasatinib moiety // Mendeleev Communications. 2026.
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Bortnevskaya Y. S., Karpechenko N. Yu., Bragina N. A., Zhdanova K. A. Synthesis of new cationic porphyrin with targeting Dasatinib moiety // Mendeleev Communications. 2026.
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TY - JOUR
DO - 10.71267/mencom.8088
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8088
TI - Synthesis of new cationic porphyrin with targeting Dasatinib moiety
T2 - Mendeleev Communications
AU - Bortnevskaya, Yuliya Sergeevna
AU - Karpechenko, Natalia Yu
AU - Bragina, Natal'ya Aleksandrovna
AU - Zhdanova, Kseniya Aleksandrovna
PY - 2026
DA - 2026/09/23
PB - Mendeleev Communications
ER -
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@article{2026_Bortnevskaya,
author = {Yuliya Sergeevna Bortnevskaya and Natalia Yu Karpechenko and Natal'ya Aleksandrovna Bragina and Kseniya Aleksandrovna Zhdanova},
title = {Synthesis of new cationic porphyrin with targeting Dasatinib moiety},
journal = {Mendeleev Communications},
year = {2026},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8088},
doi = {10.71267/mencom.8088}
}
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Keywords

meso-arylporphyrins
antitumor cytotoxicity
click reaction
Dasatinib
photodynamic therapy
pyridinium compounds
small-molecule-targeted tyrosine kinase inhibitor

Abstract

A new photosensitizer based on Dasatinib derivative and cationic pyridinium-containing zinc meso-arylporphyrinate was obtained using the CuI-catalyzed azide–alkyne cycloaddition (CuAAC) at the key step. Submicromolar values of IC50 for the targeted compound were determined using cell lines MCF7 and A431.

Funders

Russian Science Foundation
22-73-10176-P
Ministry of Education and Science of the Russian Federation
075-15-2025-548

References

2.
Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single‐Component Organic Phototherapeutic Agents
Fang L., Chen Z., Dai J., Pan Y., Tu Y., Meng Q., Diao Y., Yang S., Guo W., Li L., Liu J., Wen H., Hua K., Hang L., Fang J., et. al.
Advanced Science, 2025
3.
The Current Status of Photodynamic Therapy in Cancer Treatment
Jiang W., Liang M., Lei Q., Li G., Wu S.
Cancers, 2023
4.
Recent Advancement in Photosensitizers for Photodynamic Therapy
Singh P.P., Sinha S., Gahtori P., Mishra D.N., Pandey G., Srivastava V.
Dyes and Pigments, 2024
5.
Near Infrared (NIR) absorbing dyes as promising photosensitizer for photo dynamic therapy
Chinna Ayya Swamy P., Sivaraman G., Priyanka R.N., Raja S.O., Ponnuvel K., Shanmugpriya J., Gulyani A.
Coordination Chemistry Reviews, 2020
6.
Natural Chlorin e 6 Derivative Containing a Cationic Dimethyl Piperazinyl Moiety for Efficient Photodynamic Therapy of Cancer
Kustov A.V., Morshnev P.K., Smirnova N.L., Kustova T.V., Zorina T.E., Zorin V.P., Gagua A.K., Fomin N.S., Lyapin D.S., Fomichev M.D., Berezin D.B., Abramova O.B.
ACS Omega, 2026
7.
Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy
Fernandes S.R., Fernandes R., Sarmento B., Pereira P.M., Tomé J.P.
Organic and Biomolecular Chemistry, 2019
8.
Tyrosine kinase inhibitors for solid tumors in the past 20 years (2001–2020)
Huang L., Jiang S., Shi Y.
Journal of Hematology and Oncology, 2020
9.
FDA-approved small-molecule kinase inhibitors
Wu P., Nielsen T.E., Clausen M.H.
Trends in Pharmacological Sciences, 2015
10.
Advanced photodynamic therapy with an engineered M13 phage targeting EGFR: Mitochondrial localization and autophagy induction in ovarian cancer cell lines
Bortot B., Apollonio M., Baj G., Andolfi L., Zupin L., Crovella S., di Giosia M., Cantelli A., Saporetti R., Ulfo L., Petrosino A., Di Lorenzo G., Romano F., Ricci G., Mongiat M., et. al.
Free Radical Biology and Medicine, 2022
11.
Water-Soluble Chlorin/Arylaminoquinazoline Conjugate for Photodynamic and Targeted Therapy
Otvagin V.F., Kuzmina N.S., Krylova L.V., Volovetsky A.B., Nyuchev A.V., Gavryushin A.E., Meshkov I.N., Gorbunova Y.G., Romanenko Y.V., Koifman O.I., Balalaeva I.V., Fedorov A.Y.
Journal of Medicinal Chemistry, 2019
12.
Long‐term results of frontline dasatinib in chronic myeloid leukemia
Maiti A., Cortes J.E., Patel K.P., Masarova L., Borthakur G., Ravandi F., Verstovsek S., Ferrajoli A., Estrov Z., Garcia‐Manero G., Kadia T.M., Nogueras‐González G.M., Skinner J., Poku R., DellaSala S., et. al.
Cancer, 2020
13.
Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling
Nautiyal J., Majumder P., Patel B.B., Lee F.Y., Majumdar A.P.
Cancer Letters, 2009
14.
Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor
Shah N.P., Tran C., Lee F.Y., Chen P., Norris D., Sawyers C.L.
Science, 2004
15.
A small molecule nanodrug consisting of pH-sensitive ortho ester–dasatinib conjugate for cancer therapy
Gao J., Qiao Z., Liu S., Xu J., Wang S., Yang X., Wang X., Tang R.
European Journal of Pharmaceutics and Biopharmaceutics, 2021
17.
Unleashing the power of porphyrin photosensitizers: Illuminating breakthroughs in photodynamic therapy
Alibasha A., Khan S., Chatterjee T., Ghosh M.
Journal of Photochemistry and Photobiology B: Biology, 2023
18.
Kuzmina N.S., Otvagin V.F., Krylova L.V., Nyuchev A.V., Romanenko Y.V., Koifman O.I., Balalaeva I.V., Fedorov A.Y.
Mendeleev Communications, 2020
19.
Usanyov Alexey Yu, Sukoreva Sofia M, Prokopova Nadezhda V, Gradova Margaret Alekseevna, Karpechenko Natalia Yu, Bragina Natal'ya Aleksandrovna, Zhdanova Kseniya Aleksandrovna
Mendeleev Communications, 2025
20.
Synthesis, Molecular Docking, and Biological Activity of New EGFR-Targeted Photosensitizers Based on Cationic Porphyrins Encapsulated into Pluronic F127 Micelles
Bortnevskaya Y.S., Zakharov N.S., Senkov V.S., Gradova M.A., Karpechenko N.Y., Nikolskaya E.D., Mollaeva M.R., Yabbarov N.G., Novikov A.S., Bragina N.A., Zhdanova K.A.
Molecular Pharmaceutics, 2025
21.
Bortnevskaya Y.S., Malikova V.A., Karpechenko N.Y., Bragina N.A., Zhdanova K.A.
Mendeleev Communications, 2024
22.
The Synthesis of Meso-Substituted Porphyrins
Lindsey J.S.
Transition Metal Complexes as Drugs and Chemotherapeutic Agents, 1994
23.
Synthesis and photochemistry of free base and zinc tetraaryl porphyrins mono-substituted with tungsten pentacarbonyl via a pyridine linker
Aspley C.J., Lindsay Smith J.R., Perutz R.N., Pursche D.
Journal of the Chemical Society Dalton Transactions, 2002
24.
Click chemistry: function follows form
Finn M.G., Fokin V.V.
Chemical Society Reviews, 2010
26.
Solubilization of n-hexadecane by micellar solutions of trehalolipid - surfactants of biological origin
Nechaeva I.A., Parfenova A.S., Filippova A.S., Filonov A.E.
Fine Chemical Technologies, 2024
27.
Solvation, Cancer Cell Photoinactivation and the Interaction of Chlorin Photosensitizers with a Potential Passive Carrier Non-Ionic Surfactant Tween 80
Kustov A.V., Morshnev P.K., Kukushkina N.V., Smirnova N.L., Berezin D.B., Karimov D.R., Shukhto O.V., Kustova T.V., Belykh D.V., Mal’shakova M.V., Zorin V.P., Zorina T.E.
International Journal of Molecular Sciences, 2022