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Cyclopalladated derivatives of thiophosphorylated 2-(pyridin-2-yl)acetamides: synthesis and cytotoxic effects

Svetlana Grirorievna Churusova 1
Svetlana Grirorievna Churusova
, 
Aleksandr V Konovalov 1
Aleksandr V Konovalov
,  , 
Ekaterina Yu Rybalkina 2
Ekaterina Yu Rybalkina
,  , 
Anastasia A Danshina 1, 4
Anastasia A Danshina
, 
Aleksandr Sergeevich Peregudov 1
Aleksandr Sergeevich Peregudov
, 
Zinaida Sergeevna Klemenkova 1
Zinaida Sergeevna Klemenkova
, 
Vladimir Andreevich Kozlov 1
Vladimir Andreevich Kozlov
10.71267/mencom.8084
Published 23 September 2026
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Churusova S. G. et al. Cyclopalladated derivatives of thiophosphorylated 2-(pyridin-2-yl)acetamides: synthesis and cytotoxic effects // Mendeleev Communications. 2026.
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Churusova S. G., Konovalov A. V., Aleksanyan D. V., Rybalkina E. Yu., Nelyubina Y. V., Danshina A. A., Peregudov A. S., Klemenkova Z. S., Kozlov V. A. Cyclopalladated derivatives of thiophosphorylated 2-(pyridin-2-yl)acetamides: synthesis and cytotoxic effects // Mendeleev Communications. 2026.
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TY - JOUR
DO - 10.71267/mencom.8084
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8084
TI - Cyclopalladated derivatives of thiophosphorylated 2-(pyridin-2-yl)acetamides: synthesis and cytotoxic effects
T2 - Mendeleev Communications
AU - Churusova, Svetlana Grirorievna
AU - Konovalov, Aleksandr V
AU - Aleksanyan, Diana Vladimirovna
AU - Rybalkina, Ekaterina Yu
AU - Nelyubina, Yulia Vladimirovna
AU - Danshina, Anastasia A
AU - Peregudov, Aleksandr Sergeevich
AU - Klemenkova, Zinaida Sergeevna
AU - Kozlov, Vladimir Andreevich
PY - 2026
DA - 2026/09/23
PB - Mendeleev Communications
ER -
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@article{2026_Churusova,
author = {Svetlana Grirorievna Churusova and Aleksandr V Konovalov and Diana Vladimirovna Aleksanyan and Ekaterina Yu Rybalkina and Yulia Vladimirovna Nelyubina and Anastasia A Danshina and Aleksandr Sergeevich Peregudov and Zinaida Sergeevna Klemenkova and Vladimir Andreevich Kozlov},
title = {Cyclopalladated derivatives of thiophosphorylated 2-(pyridin-2-yl)acetamides: synthesis and cytotoxic effects},
journal = {Mendeleev Communications},
year = {2026},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8084},
doi = {10.71267/mencom.8084}
}
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Keywords

2-(pyridin-2-yl)acetamides
cyclometalation
cytotoxicity
palladium
pincer complexes

Abstract

The direct cyclopalladation of thiophosphoryl-substituted 2-(pyridin-2-yl)acetamides, readily obtained by the carbodiimide-mediated coupling of 2-(pyridin-2-yl)acetic acid with (α-aminoalkyl)diphenylphosphine sulfides, smoothly afforded two novel PdII S,N,N-pincer complexes, which were characterized by NMR and IR spectroscopy as well as X-ray crystallography. The resulting complexes displayed potent cytotoxic activity against several solid and hematopoietic human cancer cell lines, with higher selectivity and broader scope of action than those of the earlier reported related palladocycles.

Funders

Russian Science Foundation
22-73-10044-P
Ministry of Education and Science of the Russian Federation
075-03-2026-024

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