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Novel triazole-based dinitrosyl iron–sulfur complex as an effective phosphodiesterase inhibitor

Nataliya Alekseevna Sanina 1
Nataliya Alekseevna Sanina
, 
Svyatoslav Yaroslavovich Gadomsky 1
Svyatoslav Yaroslavovich Gadomsky
,  , 
Andrey Nikolaevich Utenyshev 1
Andrey Nikolaevich Utenyshev
, 
Olesya Viktorovna Pokidova 1
Olesya Viktorovna Pokidova
, 
Ludmila M Matveeva 1
Ludmila M Matveeva
, 
Anastasya Aleksandrovna Balakina 1
Anastasya Aleksandrovna Balakina
, 
10.71267/mencom.8083
Published 23 September 2026
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Sanina N. A. et al. Novel triazole-based dinitrosyl iron–sulfur complex as an effective phosphodiesterase inhibitor // Mendeleev Communications. 2026.
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Sanina N. A., Gadomsky S. Y., Emelyanova N. S., Utenyshev A. N., Pokidova O. V., Matveeva L. M., Balakina A. A., Aldoshin S. M. Novel triazole-based dinitrosyl iron–sulfur complex as an effective phosphodiesterase inhibitor // Mendeleev Communications. 2026.
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TY - JOUR
DO - 10.71267/mencom.8083
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8083
TI - Novel triazole-based dinitrosyl iron–sulfur complex as an effective phosphodiesterase inhibitor
T2 - Mendeleev Communications
AU - Sanina, Nataliya Alekseevna
AU - Gadomsky, Svyatoslav Yaroslavovich
AU - Emelyanova, Nina Sergeevna
AU - Utenyshev, Andrey Nikolaevich
AU - Pokidova, Olesya Viktorovna
AU - Matveeva, Ludmila M
AU - Balakina, Anastasya Aleksandrovna
AU - Aldoshin, Sergei Mikhailovich
PY - 2026
DA - 2026/09/23
PB - Mendeleev Communications
ER -
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@article{2026_Sanina,
author = {Nataliya Alekseevna Sanina and Svyatoslav Yaroslavovich Gadomsky and Nina Sergeevna Emelyanova and Andrey Nikolaevich Utenyshev and Olesya Viktorovna Pokidova and Ludmila M Matveeva and Anastasya Aleksandrovna Balakina and Sergei Mikhailovich Aldoshin},
title = {Novel triazole-based dinitrosyl iron–sulfur complex as an effective phosphodiesterase inhibitor},
journal = {Mendeleev Communications},
year = {2026},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8083},
doi = {10.71267/mencom.8083}
}
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Keywords

4H-1,2,4-triazole-3-thiols
cGMP
DFT
MTT
NO donors
PDEs
spectroscopy

Abstract

A novel low-cytotoxic dinitrosyl iron complex of the general formula [Fe(SL)2(NO)2], where SL is 5-[2-(1H-benzotriazol-1-yl)ethyl]-4H-1,2,4-triazole-3-thiolyl, was prepared. Its structure and properties were investigated theoretically by DFT and experimentally using IR, EPR and 57Fe Mössbauer spectroscopy. It was found that the complex exhibits high inhibitory activity against phosphodiesterase and is also capable of generating NO, which indicates the likelihood of its high anti-inflammatory activity due to the specific impact on two therapeutic targets simultaneously (i.e., phosphodiesterase and soluble guanylate cyclase).

Funders

Russian Science Foundation
25-73-20036