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Synthesis of water-soluble BODIPY conjugate with closo-decaborate anion and its in vivo biodistribution study

Ilya A Mezentsev 1, 2
Ilya A Mezentsev
, 
Nadezhda Vadimovna Dudarova 1
Nadezhda Vadimovna Dudarova
, 
Olga Borisovna Zhidkova 1
Olga Borisovna Zhidkova
, 
Anna Aleksandrovna Druzina 1
Anna Aleksandrovna Druzina
,  , 
Vsevolod A Skribitsky 3
Vsevolod A Skribitsky
, 
Anton A Kasianov 3
Anton A Kasianov
, 
Kristina E Shpakova 3
Kristina E Shpakova
, 
Yulia A Finogenova 3
Yulia A Finogenova
, 
Alexey A Lipengolts 3
Alexey A Lipengolts
, 
Elena Yu Grigorieva 3
Elena Yu Grigorieva
, 
Vladimir Iosifovich Bregadze 1
Vladimir Iosifovich Bregadze
10.71267/mencom.8077
Published 23 September 2026
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Mezentsev I. A. et al. Synthesis of water-soluble BODIPY conjugate with closo-decaborate anion and its in vivo biodistribution study // Mendeleev Communications. 2026.
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Mezentsev I. A., Dudarova N. V., Zhidkova O. B., Druzina A. A., Kosenko I. D., Skribitsky V. A., Kasianov A. A., Shpakova K. E., Finogenova Y. A., Lipengolts A. A., Grigorieva E. Yu., Bregadze V. I. Synthesis of water-soluble BODIPY conjugate with closo-decaborate anion and its in vivo biodistribution study // Mendeleev Communications. 2026.
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TY - JOUR
DO - 10.71267/mencom.8077
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8077
TI - Synthesis of water-soluble BODIPY conjugate with closo-decaborate anion and its in vivo biodistribution study
T2 - Mendeleev Communications
AU - Mezentsev, Ilya A
AU - Dudarova, Nadezhda Vadimovna
AU - Zhidkova, Olga Borisovna
AU - Druzina, Anna Aleksandrovna
AU - Kosenko, Irina Dmitrievna
AU - Skribitsky, Vsevolod A
AU - Kasianov, Anton A
AU - Shpakova, Kristina E
AU - Finogenova, Yulia A
AU - Lipengolts, Alexey A
AU - Grigorieva, Elena Yu
AU - Bregadze, Vladimir Iosifovich
PY - 2026
DA - 2026/09/23
PB - Mendeleev Communications
ER -
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@article{2026_Mezentsev,
author = {Ilya A Mezentsev and Nadezhda Vadimovna Dudarova and Olga Borisovna Zhidkova and Anna Aleksandrovna Druzina and Irina Dmitrievna Kosenko and Vsevolod A Skribitsky and Anton A Kasianov and Kristina E Shpakova and Yulia A Finogenova and Alexey A Lipengolts and Elena Yu Grigorieva and Vladimir Iosifovich Bregadze},
title = {Synthesis of water-soluble BODIPY conjugate with closo-decaborate anion and its in vivo biodistribution study},
journal = {Mendeleev Communications},
year = {2026},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8077},
doi = {10.71267/mencom.8077}
}
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Keywords

‘click’ reaction
closo-decaborate
in vivo study
azido derivative
BODIPY
boron neutron capture therapy
fluorescent labeling

Abstract

A water-soluble conjugate of closo-decaborate derivative with BODIPY was synthesized using the copper-catalyzed azide–alkyne cycloaddition. The absorption and emission spectra of the formed conjugate show that the addition of a boron cluster weakens the fluorescence of the initial azido derivative of BODIPY. The biodistribution of this conjugate in the in in vivo study on laboratory animals reveales a high tumor-to-normal-tissue ratio, making it a potential candidate for boron neutron capture therapy.

Funders

Russian Science Foundation
24-73-10090

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