Keywords
3,7-diazabicyclo[3.3.1]nonane
allosteric modulators
AMPA receptor
benzo[d][1,3]dioxole-5-carboxamide
glutamatergic system
indane
oxidative stress
spatial memory and learning
Abstract
A promising positive allosteric modulator of the AMPA receptor, tricyclic cage 3,7-diazabicyclo[3.3.1]nonane derivative bearing 2-(5-piperonylcarbonylamino)indane moiety, has been synthesized in gram quantity. The in vitro studies have demonstrated significant neuroprotective effect in nanomolar and subnanomolar concentrations in a model of oxidative stress. In vivo studies have shown improved spatial memory and learning in the behavioral tests in mice.
Funders
Russian Science Foundation
22-15-00041
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