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Synthesis of new N',N'-succinoylbenzohydrazide derivatives bearing bridged 9-R-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene framework

Gulnara Nazifovna Kadikova 1
Gulnara Nazifovna Kadikova
, 
Ekaterina Sergeevna Meshcheryakova 1
Ekaterina Sergeevna Meshcheryakova
, 
Leonard Mukhibovich Khalilov 1
Leonard Mukhibovich Khalilov
10.71267/mencom.8069
Published 23 September 2026
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Kadikova G. N., Meshcheryakova E. S., Khalilov L. M. Synthesis of new N',N'-succinoylbenzohydrazide derivatives bearing bridged 9-R-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene framework // Mendeleev Communications. 2026.
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Kadikova G. N., Meshcheryakova E. S., Khalilov L. M. Synthesis of new N',N'-succinoylbenzohydrazide derivatives bearing bridged 9-R-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene framework // Mendeleev Communications. 2026.
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TY - JOUR
DO - 10.71267/mencom.8069
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8069
TI - Synthesis of new N',N'-succinoylbenzohydrazide derivatives bearing bridged 9-R-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene framework
T2 - Mendeleev Communications
AU - Kadikova, Gulnara Nazifovna
AU - Meshcheryakova, Ekaterina Sergeevna
AU - Khalilov, Leonard Mukhibovich
PY - 2026
DA - 2026/09/23
PB - Mendeleev Communications
ER -
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@article{2026_Kadikova,
author = {Gulnara Nazifovna Kadikova and Ekaterina Sergeevna Meshcheryakova and Leonard Mukhibovich Khalilov},
title = {Synthesis of new N',N'-succinoylbenzohydrazide derivatives bearing bridged 9-R-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene framework},
journal = {Mendeleev Communications},
year = {2026},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8069},
doi = {10.71267/mencom.8069}
}
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Keywords

N',N'-succinoylbenzohydrazide
4-[(4-fluorophenoxy)methyl]benzohydrazide
4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene
4-oxatetracyclo[5.3.2.02,6.08,10]dodec-11-ene
bridged compounds
hydrazides

Abstract

Reactions between 9-R-4-oxatetracyclo[5.3.2.02,6.08,10]dodec-11-ene-3,5-diones (incorporating succinic anhydride moiety) and 4-[(4-fluorophenoxy)methyl]benzohydrazide afford the corresponding N',N'-succinoylbenzohydrazides bearing bridged 9-R-4-benzamido-3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene framework. NMR spectroscopy and X-ray diffraction analysis showed that the synthesized compounds retain the stereochemistry of the starting anhydrides when the imide and cyclopropane fragments are syn-oriented relative to the ethene bridge.

Funders

Ministry of Education and Science of the Russian Federation
FMRS-2025-0047

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