Home / Articles / 1-(Aminoacyloxy)germatranes: synthesis, identification and bactericidal activity

1-(Aminoacyloxy)germatranes: synthesis, identification and bactericidal activity

Denis Vital'evich Lezov 1
Denis Vital'evich Lezov
, 
Gregory K Savelyev 1, 2, 3
Gregory K Savelyev
, 
Tat'yana Aleksandrovna Kochina 1
Tat'yana Aleksandrovna Kochina
, 
Aleksandr Vladimirovich Piskunov 4
Aleksandr Vladimirovich Piskunov
, 
Valerii Leonidovich Ugolkov 1
Valerii Leonidovich Ugolkov
, 
Maria N Romanenko 2, 3
Maria N Romanenko
, 
Anton E Shikov 2
Anton E Shikov
, 
Kirill S Antonets 2, 3
Kirill S Antonets
, 
Anton A Nizhnikov 2, 3
Anton A Nizhnikov
1 I. V. Grebenshchikov Institute of Silicate Chemistry, National Research Centre ‘Kurchatov Institute’, 199034 St. Petersburg, Russian Federation
2 All-Russian Research Institute for Agricultural Microbiology, 196608 St. Petersburg, Russian Federation
3 Department of Biology, St. Petersburg State University, 199034 St. Petersburg, Russian Federation
10.71267/mencom.8063
Published 23 September 2026
Communication
0
Share
Cite this
GOST
 | 
Cite this
GOST
Copy cite
Lezov D. V. et al. 1-(Aminoacyloxy)germatranes: synthesis, identification and bactericidal activity // Mendeleev Communications. 2026.
GOST all authors (up to 50)
Copy cite
Lezov D. V., Savelyev G. K., Kochina T. A., Piskunov A. V., Ugolkov V. L., Romanenko M. N., Shikov A. E., Antonets K. S., Nizhnikov A. A. 1-(Aminoacyloxy)germatranes: synthesis, identification and bactericidal activity // Mendeleev Communications. 2026.
RIS
 | 
Cite this
RIS
Copy cite
TY - JOUR
DO - 10.71267/mencom.8063
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8063
TI - 1-(Aminoacyloxy)germatranes: synthesis, identification and bactericidal activity
T2 - Mendeleev Communications
AU - Lezov, Denis Vital'evich
AU - Savelyev, Gregory K
AU - Kochina, Tat'yana Aleksandrovna
AU - Piskunov, Aleksandr Vladimirovich
AU - Ugolkov, Valerii Leonidovich
AU - Romanenko, Maria N
AU - Shikov, Anton E
AU - Antonets, Kirill S
AU - Nizhnikov, Anton A
PY - 2026
DA - 2026/09/23
PB - Mendeleev Communications
ER -
BibTex
Cite this
BibTex (up to 50 authors)
Copy cite
@article{2026_Lezov,
author = {Denis Vital'evich Lezov and Gregory K Savelyev and Tat'yana Aleksandrovna Kochina and Aleksandr Vladimirovich Piskunov and Valerii Leonidovich Ugolkov and Maria N Romanenko and Anton E Shikov and Kirill S Antonets and Anton A Nizhnikov},
title = {1-(Aminoacyloxy)germatranes: synthesis, identification and bactericidal activity},
journal = {Mendeleev Communications},
year = {2026},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8063},
doi = {10.71267/mencom.8063}
}
Views / Visits
48 / 48

Keywords

1-aminoacyloxygermatranes
amino acids
aqueous medium, hypervalent state
biological activity
germanium compounds
transannular bond
triethanolamine

Abstract

The reactions of germanium glycinate, L-α-alaninate, β-alaninate, L-valinate, L-cysteinate, L-leucinate, L-serinate, D,L-methioninate, and D,L-tryptophanate with triethanolamine N(CH2CH2OH)3 afforded new compounds of the 1-(aminoacyloxy)germatrane series. Their potential biological activity against a set of bacterial species was assessed using in vitro experiments.

Funders

Russian Science Foundation
24-16-00284
Ministry of Education and Science of the Russian Federation
1023032900385-8-1.4.3

References

2.
New intracomplex compounds of pentacoordinate germanium. Hypogermatranes, Ge-substituted (N→Ge) 2-oxa-5-aza-1-germacyclopentanes
Voronkov M.G., Samokhin G.S., Vrazhnov D.V., Kochina T.A.
Russian Journal of General Chemistry, 2012
3.
Reaction of 1-germatranol hydrate with carboxylic acids
Baryshok V.P., Le N.T.
Russian Journal of General Chemistry, 2015
4.
The role of germanium in diseases: exploring its important biological effects
Luo X., Sun J., Kong D., Lei Y., Gong F., Zhang T., Shen Z., Wang K., Luo H., Xu Y.
Journal of Translational Medicine, 2023
5.
Biological Activity of Organogermanium Compounds (A Review)
Menchikov L.G., Ignatenko M.A.
Pharmaceutical Chemistry Journal, 2013
6.
Synthesis of 1-germatranol and its C-substituted derivatives
Voronkov M.G., Ovchinnikova Z.A., Baryshok V.P.
Russian Chemical Bulletin, 1987
7.
ref-10.71267-mendc7542-1-7-1-0
M. M. Rasulov, P. A. Storozhenko, T. A. Snisarenko, M. I. Susova, V. P. Baryshok, M. G. Voronkov, T. A. Podgorbunskaya, A. Yu. Fedorin and A. P. Orzhekovsky
2015
8.
2-(Germatran-1-yloxy)ethylamine as an inhibitor of the total activity of mononuclear alkaline phospholipase A2
Zhigacheva I.V., Baryshok V.P., Rasulov M.M., Storozhenko P.A.
Russian Chemical Bulletin, 2021
9.
Biologically Active Coordination Compounds of Germanium. Synthesis and Physicochemical Properties
Kadomtseva A.V., Mochalov G.M., Kuzina O.V.
Russian Journal of Organic Chemistry, 2021
12.
Germatranes and their Analogs. Synthesis, Structure, and Reactivity. (Review)
Karlov S.S., Zaitseva G.S.
Chemistry of Heterocyclic Compounds, 2001
14.
Interaction of simple amino acids (glycine, α-alanine, β-alanine and L-valine) with germatranol hydrate
Ignatyev I.S., Lezov D.V., Kondratenko Y.A., Kochina T.A.
Journal of Molecular Structure, 2022
15.
ref-10.71267-mendc7542-1-15-1-0
A. D. Isaev, I. V. Ambrosov and T. O. Manasherov
2017
16.
ref-10.71267-mendc7542-1-16-1-0
A. D. Isaev, T. O. Manasherov, I. V. Ambrosov and S. K. Matelo
2013
17.
Exploring novel bacterial terpene synthases
Reddy G.K., Leferink N.G., Umemura M., Ahmed S.T., Breitling R., Scrutton N.S., Takano E.
PLoS ONE, 2020
19.
Pseudomonas syringae: what it takes to be a pathogen
Xin X., Kvitko B., He S.Y.
Nature Reviews Microbiology, 2018
20.
Pseudomonas
Bisht N., Dixit R., Chauhan P.S.
2025
21.
Molecular characterization of Pectobacterium atrosepticum infecting potato and its management through chemicals
Hameed A., Zeeshan M., Binyamin R., Alam M.W., Ali S., Zaheer M.S., Ali H., Riaz M.W., Ali H.H., Elshikh M.S., Alarjani K.M.
PeerJ, 2024