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New 1,2,3-triazole-containing hydroxamic acids as HDACs inhibitors with chemosensitizing properties

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10.71267/mencom.8054
Published 28 July 2026
Communication , Volume 36, Issue 5, 531-533
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Aleksandrova Y. R., Brel V. K., Neganova M. E. New 1,2,3-triazole-containing hydroxamic acids as HDACs inhibitors with chemosensitizing properties // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 531-533.
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Aleksandrova Y. R., Brel V. K., Neganova M. E. New 1,2,3-triazole-containing hydroxamic acids as HDACs inhibitors with chemosensitizing properties // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 531-533.
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TY - JOUR
DO - 10.71267/mencom.8054
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8054
TI - New 1,2,3-triazole-containing hydroxamic acids as HDACs inhibitors with chemosensitizing properties
T2 - Mendeleev Communications
AU - Aleksandrova, Yulia Romanovna
AU - Brel, Valery Kuzmich
AU - Neganova, Margarita Evgenievna
PY - 2026
DA - 2026/07/28
PB - Mendeleev Communications
SP - 531-533
IS - 5
VL - 36
ER -
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@article{2026_Aleksandrova,
author = {Yulia Romanovna Aleksandrova and Valery Kuzmich Brel and Margarita Evgenievna Neganova},
title = {New 1,2,3-triazole-containing hydroxamic acids as HDACs inhibitors with chemosensitizing properties},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8054},
number = {5},
pages = {531--533},
doi = {10.71267/mencom.8054}
}
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Aleksandrova, Yulia Romanovna, et al. “New 1,2,3-triazole-containing hydroxamic acids as HDACs inhibitors with chemosensitizing properties.” Mendeleev Communications, vol. 36, no. 5, Jul. 2026, pp. 531-533. https://mendcomm.colab.ws/publications/10.71267/mencom.8054.
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Keywords

1,2,3-triazoles
azide--alkyne cycloaddition
cancer cells
cell death
chemosensitizing effect
cisplatin
HDAC inhibitors
histone deacetylases
hydroxamic acids

Abstract

A new series of hydroxamic acids containing a 1,2,3-triazole moiety were obtained by the cycloaddition of methyl (2-azidoethoxy)acetate to a variety of acetylenes followed by treatment with hydroxylamine. The evaluation of their inhibitory activity against HDAC1, HDAC3, and HDAC8 revealed that N-hydroxy-2-[4-(4-pentylphenyl)-1H-1,2,3- triazol-1-yl]ethoxyacetamide showed the strongest HDAC inhibition and markedly enhanced cisplatin-induced apoptosis and antiproliferative effects in A431 cells, reducing the cisplatin IC50 from 15.64 ± 0.53 to 6.46 ± 0.87 μm (p < 0.05).

Funders

Russian Science Foundation
25-73-20033

References

1.
The Hydroxamic Acids as Potential Anticancer and Neuroprotective Agents
Neganova M.E., Klochkov S.G., Aleksandrova Y.R., Aliev G.
Current Medicinal Chemistry, 2020