Home / Articles / Synthesis of functionalized 2-(2-pyrrolyl)dihydropyridines and 3(4)-amino-3-pyrrolylalkenoates from pyrrolylpropynoates and aminomalonate

Synthesis of functionalized 2-(2-pyrrolyl)dihydropyridines and 3(4)-amino-3-pyrrolylalkenoates from pyrrolylpropynoates and aminomalonate

, 
Ivan Vladimirovich Saliy 1
Ivan Vladimirovich Saliy
, 
Igor Alekseevich Ushakov 1
Igor Alekseevich Ushakov
10.71267/mencom.8048
Published 28 July 2026 , received 23 March 2026
Communication , Volume 36, Issue 5, 557-559
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Gotsko M. D., Saliy I. V., Ushakov I. A. Synthesis of functionalized 2-(2-pyrrolyl)dihydropyridines and 3(4)-amino-3-pyrrolylalkenoates from pyrrolylpropynoates and aminomalonate // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 557-559.
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Gotsko M. D., Saliy I. V., Ushakov I. A. Synthesis of functionalized 2-(2-pyrrolyl)dihydropyridines and 3(4)-amino-3-pyrrolylalkenoates from pyrrolylpropynoates and aminomalonate // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 557-559.
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TY - JOUR
DO - 10.71267/mencom.8048
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8048
TI - Synthesis of functionalized 2-(2-pyrrolyl)dihydropyridines and 3(4)-amino-3-pyrrolylalkenoates from pyrrolylpropynoates and aminomalonate
T2 - Mendeleev Communications
AU - Gotsko, Maxim Dmitrievich
AU - Saliy, Ivan Vladimirovich
AU - Ushakov, Igor Alekseevich
PY - 2026
DA - 2026/07/28
PB - Mendeleev Communications
SP - 557-559
IS - 5
VL - 36
ER -
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@article{2026_Gotsko,
author = {Maxim Dmitrievich Gotsko and Ivan Vladimirovich Saliy and Igor Alekseevich Ushakov},
title = {Synthesis of functionalized 2-(2-pyrrolyl)dihydropyridines and 3(4)-amino-3-pyrrolylalkenoates from pyrrolylpropynoates and aminomalonate},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8048},
number = {5},
pages = {557--559},
doi = {10.71267/mencom.8048}
}
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Gotsko, Maxim Dmitrievich, et al. “Synthesis of functionalized 2-(2-pyrrolyl)dihydropyridines and 3(4)-amino-3-pyrrolylalkenoates from pyrrolylpropynoates and aminomalonate.” Mendeleev Communications, vol. 36, no. 5, Jul. 2026, pp. 557-559. https://mendcomm.colab.ws/publications/10.71267/mencom.8048.
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Keywords

1,4-dihydropyridines
3(4)-aminoalk-2-enoates
aminomalonate
catalysis
chemoselectivity
Cyclization
Michael addition
pharmacology
propynoates
pyrroles

Abstract

3-(2-Pyrrolyl)propynoates variously substituted in the pyrrole moiety add aminomalonate (excess Cs2CO3, reflux in MeCN, 6 h) to chemoselectively afford either aminoalkyl or alkylamino Michael adducts depending on the reactant ratio. In cases of 3-(1-alkyl-2-pyrrolyl)propynoates and 3-bromopropynoate as the additional co-reactant, 2-(1-alkyl-2- pyrrolyl)-1,4-dihydropyridines were formed.

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