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Malonate-functionalised 4-hydroxyquinolin-2(1H)-ones: a new subset of quinolinone derivatives

Dmitry A Grishin 1
Dmitry A Grishin
, 
Kamilla I Zaitova 1
Kamilla I Zaitova
, 
Rostislav A Petrov 1
Rostislav A Petrov
, 
Nikolai D Dagaev 2
Nikolai D Dagaev
, 
Anton R Izzi 2
Anton R Izzi
, 
Dmitry Aleksandrovich Skvortsov 1
Dmitry Aleksandrovich Skvortsov
,  , 
Roman L'vovich Antipin 1
Roman L'vovich Antipin
, 
2 Department of Bioengineering and Bioinformatics, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation
10.71267/mencom.8041
Published 28 July 2026 , received 13 March 2026
Communication , Volume 36, Issue 5, 548-550
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Grishin D. A. et al. Malonate-functionalised 4-hydroxyquinolin-2(1H)-ones: a new subset of quinolinone derivatives // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 548-550.
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Grishin D. A., Zaitova K. I., Petrov R. A., Dagaev N. D., Izzi A. R., Skvortsov D. A., Grishin Y. K., Antipin R. L., Beloglazkina E. K. Malonate-functionalised 4-hydroxyquinolin-2(1H)-ones: a new subset of quinolinone derivatives // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 548-550.
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TY - JOUR
DO - 10.71267/mencom.8041
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8041
TI - Malonate-functionalised 4-hydroxyquinolin-2(1H)-ones: a new subset of quinolinone derivatives
T2 - Mendeleev Communications
AU - Grishin, Dmitry A
AU - Zaitova, Kamilla I
AU - Petrov, Rostislav A
AU - Dagaev, Nikolai D
AU - Izzi, Anton R
AU - Skvortsov, Dmitry Aleksandrovich
AU - Grishin, Yuri Konstantinovich
AU - Antipin, Roman L'vovich
AU - Beloglazkina, Elena Kimovna
PY - 2026
DA - 2026/07/28
PB - Mendeleev Communications
SP - 548-550
IS - 5
VL - 36
ER -
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@article{2026_Grishin,
author = {Dmitry A Grishin and Kamilla I Zaitova and Rostislav A Petrov and Nikolai D Dagaev and Anton R Izzi and Dmitry Aleksandrovich Skvortsov and Yuri Konstantinovich Grishin and Roman L'vovich Antipin and Elena Kimovna Beloglazkina},
title = {Malonate-functionalised 4-hydroxyquinolin-2(1H)-ones: a new subset of quinolinone derivatives},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8041},
number = {5},
pages = {548--550},
doi = {10.71267/mencom.8041}
}
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Grishin, Dmitry A., et al. “Malonate-functionalised 4-hydroxyquinolin-2(1H)-ones: a new subset of quinolinone derivatives.” Mendeleev Communications, vol. 36, no. 5, Jul. 2026, pp. 548-550. https://mendcomm.colab.ws/publications/10.71267/mencom.8041.
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Keywords

4-hydroxyquinolin-2(1H)-one
Antibacterial activity
malonates
Michael addition
NMR spectroscopy

Abstract

Six new 4-hydroxyquinolin-2(1H)-one derivatives bearing malonate and 3,4-alkylenedioxyphenyl moieties were synthesised via the 1,4-Michael addition of 6-halogeno-4-hydroxyquinolin-2-ones to arylidene malonates in 54--62% yields. NMR spectroscopy revealed unusual resonance of the benzylic methine proton that was attributed to conformational exchange and/or intramolecular hydrogen bonding. The obtained compounds showed low cytotoxicity in the MTT assay and slight antibacterial activity.

Funders

Ministry of Education and Science of the Russian Federation
AAAA-A21-121012290046-4

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