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Anionic carbohydrate polymers for hydrophilization of poorly soluble antitumor compounds of the colchicine series

Vasily Vladimirovich Spiridonov 1
Vasily Vladimirovich Spiridonov
, 
Alina Radikovna Lukmanova 1
Alina Radikovna Lukmanova
,  , 
Julia A Gracheva 2
Julia A Gracheva
, 
Ekaterina Sergeevna Shchegravina 2
Ekaterina Sergeevna Shchegravina
, 
Ekaterina A Mamonova 2
Ekaterina A Mamonova
,  , 
Vladimir Izrailevich Muronets 3
Vladimir Izrailevich Muronets
, 
Aleksandr Anatol'evich Yaroslavov 1
Aleksandr Anatol'evich Yaroslavov
10.71267/mencom.8027
Published 28 July 2026 , received 24 February 2026
Communication , Volume 36, Issue 5, 585-588
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Spiridonov V. V. et al. Anionic carbohydrate polymers for hydrophilization of poorly soluble antitumor compounds of the colchicine series // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 585-588.
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Spiridonov V. V., Lukmanova A. R., Fedorov A. Y., Gracheva J. A., Shchegravina E. S., Mamonova E. A., Pozdyshev D. V., Muronets V. I., Yaroslavov A. A. Anionic carbohydrate polymers for hydrophilization of poorly soluble antitumor compounds of the colchicine series // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 585-588.
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TY - JOUR
DO - 10.71267/mencom.8027
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8027
TI - Anionic carbohydrate polymers for hydrophilization of poorly soluble antitumor compounds of the colchicine series
T2 - Mendeleev Communications
AU - Spiridonov, Vasily Vladimirovich
AU - Lukmanova, Alina Radikovna
AU - Fedorov, Alexey Yur'evich
AU - Gracheva, Julia A
AU - Shchegravina, Ekaterina Sergeevna
AU - Mamonova, Ekaterina A
AU - Pozdyshev, Denis Valerievich
AU - Muronets, Vladimir Izrailevich
AU - Yaroslavov, Aleksandr Anatol'evich
PY - 2026
DA - 2026/07/28
PB - Mendeleev Communications
SP - 585-588
IS - 5
VL - 36
ER -
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@article{2026_Spiridonov,
author = {Vasily Vladimirovich Spiridonov and Alina Radikovna Lukmanova and Alexey Yur'evich Fedorov and Julia A Gracheva and Ekaterina Sergeevna Shchegravina and Ekaterina A Mamonova and Denis Valerievich Pozdyshev and Vladimir Izrailevich Muronets and Aleksandr Anatol'evich Yaroslavov},
title = {Anionic carbohydrate polymers for hydrophilization of poorly soluble antitumor compounds of the colchicine series},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8027},
number = {5},
pages = {585--588},
doi = {10.71267/mencom.8027}
}
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Spiridonov, Vasily Vladimirovich, et al. “Anionic carbohydrate polymers for hydrophilization of poorly soluble antitumor compounds of the colchicine series.” Mendeleev Communications, vol. 36, no. 5, Jul. 2026, pp. 585-588. https://mendcomm.colab.ws/publications/10.71267/mencom.8027.
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Keywords

allocolchicine
biodegradation
carboxymethylcellulose
colchicine
cytotoxicity
histidine
hydrophilization

Abstract

The herein synthesized N-deacetylallocolchicine and its hybrid with histidine possess antitumor properties, however, their application is limited by their low solubility in aqueous media. To address this issue, they were electrostatically bound in an acidic solution to anionic carboxymethylcellulose cross-linked with biogenic Ca2+ and Mg2+ cations. The invention seems promising for the production of water-soluble and biodegradable biologically active drugs.

Funders

Ministry of Education and Science of the Russian Federation
075-15-2024-553

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