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Isothiouronium salts and thienopyridines derived from 7-azacoumarin-3-carboxamides

Alexey Vladimirovich Trifonov 1
Alexey Vladimirovich Trifonov
, 
Nurbol Orynbasaruly Appazov 2, 3
Nurbol Orynbasaruly Appazov
, 
Aiym E. Tolegen 4
Aiym E. Tolegen
, 
Ludmila Konstantinovna Kibardina 1
Ludmila Konstantinovna Kibardina
,  , 
Anna Pavlovna Lyubina 1
Anna Pavlovna Lyubina
, 
Alexandra Dmitrievna Voloshina 1
Alexandra Dmitrievna Voloshina
, 
Victor Vasil'evich Syakaev 1
Victor Vasil'evich Syakaev
,  , 
Rakhymzhan Akhmetkhanovich Turmanov 3, 5
Rakhymzhan Akhmetkhanovich Turmanov
, 
Elena Alexandrovna Chugunova 1
Elena Alexandrovna Chugunova
, 
2 ‘CNEC’ LLP, 120001 Kyzylorda, Kazakhstan
3 Korkyt Ata Kyzylorda University, 120014 Kyzylorda, Kazakhstan
4 Kazan National Research Technological University, 420015 Kazan, Russian Federation
5 ‘DPS Kyzylorda’ LLP, 120008 Kyzylorda, Kazakhstan
10.71267/mencom.8020
Published 28 July 2026 , received 16 February 2026
Communication , Volume 36, Issue 5, 551-553
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Trifonov A. V. et al. Isothiouronium salts and thienopyridines derived from 7-azacoumarin-3-carboxamides // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 551-553.
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Trifonov A. V., Appazov N. O., Tolegen A. E., Kibardina L. K., Pudovik M. A., Lyubina A. P., Voloshina A. D., Syakaev V. V., Gazizov A. S., Turmanov R. A., Chugunova E. A., Burilov A. R. Isothiouronium salts and thienopyridines derived from 7-azacoumarin-3-carboxamides // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 551-553.
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TY - JOUR
DO - 10.71267/mencom.8020
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8020
TI - Isothiouronium salts and thienopyridines derived from 7-azacoumarin-3-carboxamides
T2 - Mendeleev Communications
AU - Trifonov, Alexey Vladimirovich
AU - Appazov, Nurbol Orynbasaruly
AU - Tolegen, Aiym E.
AU - Kibardina, Ludmila Konstantinovna
AU - Pudovik, Michael Arkad'evich
AU - Lyubina, Anna Pavlovna
AU - Voloshina, Alexandra Dmitrievna
AU - Syakaev, Victor Vasil'evich
AU - Gazizov, Almir Sabirovich
AU - Turmanov, Rakhymzhan Akhmetkhanovich
AU - Chugunova, Elena Alexandrovna
AU - Burilov, Alexander Romanovich
PY - 2026
DA - 2026/07/28
PB - Mendeleev Communications
SP - 551-553
IS - 5
VL - 36
ER -
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@article{2026_Trifonov,
author = {Alexey Vladimirovich Trifonov and Nurbol Orynbasaruly Appazov and Aiym E. Tolegen and Ludmila Konstantinovna Kibardina and Michael Arkad'evich Pudovik and Anna Pavlovna Lyubina and Alexandra Dmitrievna Voloshina and Victor Vasil'evich Syakaev and Almir Sabirovich Gazizov and Rakhymzhan Akhmetkhanovich Turmanov and Elena Alexandrovna Chugunova and Alexander Romanovich Burilov},
title = {Isothiouronium salts and thienopyridines derived from 7-azacoumarin-3-carboxamides},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8020},
number = {5},
pages = {551--553},
doi = {10.71267/mencom.8020}
}
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Trifonov, Alexey Vladimirovich, et al. “Isothiouronium salts and thienopyridines derived from 7-azacoumarin-3-carboxamides.” Mendeleev Communications, vol. 36, no. 5, Jul. 2026, pp. 551-553. https://mendcomm.colab.ws/publications/10.71267/mencom.8020.
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Keywords

azacoumarin
carboxamides
cytotoxicity
isothiouronium salts
thieno[3,4-c]pyridines

Abstract

A series of isothiouronium salts were synthesized by reacting 5-chloromethyl-7-azacoumarin-3-carboxamides with thiourea. Alkaline hydrolysis of these salts led to a new family of substituted thieno[3,4-c]pyridines. The antitumor activity of the resulting compounds was assessed.

Funders

Ministry of Education and Science of the Russian Federation
Ministry of Education and Science of the Republic of Kazakhstan
AP23488720

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