Home / Articles / A novel microtubule-targeting estradiol dimer as a cell division inhibitor with minimal impact on interphase cells

A novel microtubule-targeting estradiol dimer as a cell division inhibitor with minimal impact on interphase cells

Aleksandra S Churkina 1, 2
Aleksandra S Churkina
, 
Aleksandr V Mozolevsky 3
Aleksandr V Mozolevsky
, 
Anton S Shakhov 2
Anton S Shakhov
, 
Svetlana Valer'evna Lavrushkina 2
Svetlana Valer'evna Lavrushkina
, 
Anton V Burakov 2
Anton V Burakov
, 
Olga V Ryzhikova 1
Olga V Ryzhikova
, 
Irina Borisovna Alieva 2
Irina Borisovna Alieva
, 
Elena Borisovna Averina 1
Elena Borisovna Averina
, 
2 A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation
3 Moscow Polytechnic University, 107023 Moscow, Russian Federation
10.71267/mencom.8014
Published 28 July 2026 , received 6 February 2026
Communication , Volume 36, Issue 5, 538-541
0
Share
Cite this
GOST
 | 
Cite this
GOST
Copy cite
Churkina A. S. et al. A novel microtubule-targeting estradiol dimer as a cell division inhibitor with minimal impact on interphase cells // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 538-541.
GOST all authors (up to 50)
Copy cite
Churkina A. S., Mozolevsky A. V., Shakhov A. S., Lavrushkina S. V., Burakov A. V., Ryzhikova O. V., Alieva I. B., Averina E. B., Sedenkova K. N. A novel microtubule-targeting estradiol dimer as a cell division inhibitor with minimal impact on interphase cells // Mendeleev Communications. 2026. Vol. 36. No. 5. pp. 538-541.
RIS
 | 
Cite this
RIS
Copy cite
TY - JOUR
DO - 10.71267/mencom.8014
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.8014
TI - A novel microtubule-targeting estradiol dimer as a cell division inhibitor with minimal impact on interphase cells
T2 - Mendeleev Communications
AU - Churkina, Aleksandra S
AU - Mozolevsky, Aleksandr V
AU - Shakhov, Anton S
AU - Lavrushkina, Svetlana Valer'evna
AU - Burakov, Anton V
AU - Ryzhikova, Olga V
AU - Alieva, Irina Borisovna
AU - Averina, Elena Borisovna
AU - Sedenkova, Kseniya N
PY - 2026
DA - 2026/07/28
PB - Mendeleev Communications
SP - 538-541
IS - 5
VL - 36
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors)
Copy cite
@article{2026_Churkina,
author = {Aleksandra S Churkina and Aleksandr V Mozolevsky and Anton S Shakhov and Svetlana Valer'evna Lavrushkina and Anton V Burakov and Olga V Ryzhikova and Irina Borisovna Alieva and Elena Borisovna Averina and Kseniya N Sedenkova},
title = {A novel microtubule-targeting estradiol dimer as a cell division inhibitor with minimal impact on interphase cells},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.8014},
number = {5},
pages = {538--541},
doi = {10.71267/mencom.8014}
}
MLA
Cite this
MLA
Copy cite
Churkina, Aleksandra S., et al. “A novel microtubule-targeting estradiol dimer as a cell division inhibitor with minimal impact on interphase cells.” Mendeleev Communications, vol. 36, no. 5, Jul. 2026, pp. 538-541. https://mendcomm.colab.ws/publications/10.71267/mencom.8014.
Views / Visits
36 / 36

Keywords

antiproliferative activity
microtubule-targeting drugs
Microtubules
microtubules disruption
steroid dimers
tubulin

Abstract

A novel microtubule-targeting agent, an estradiol dimer based on a bis(triazole) linker, was found to cause dose-dependent disruption of the mitotic spindle, effectively inhibiting cell division. Crucially, this effect was observed at concentrations less toxic to normal cell morphology and behavior. This work addresses the urgent need for anticancer drugs with fewer side effects and identifies a promising strategy for selectively targeting microtubules.

References

1.
Anticancer Activities of Natural and Synthetic Steroids: A Review
Mendoza Lara D.F., Hernández-Caballero M.E., Terán J.L., Ramírez J.S., Carrasco-Carballo A.
ACS Omega, 2025
2.
Anticancer Drug Conjugates Incorporating Estrogen Receptor Ligands
Zlotos D.P., Kronenberger T., Laufer S.A.
Pharmaceutics, 2022
3.
Rodionov Evgenii I, Rodionova Alina A, Zorina Alla Dmitrievna, Khoroshilova Olesya V, Suslonov Vitalii Valeryevich, Lider Elizaveta Victorovna, Golubeva Yuliya Andreevna, Klyushova Lyubov Sergeevna, Porozov Yuri Borisovich, Kuzmich Nikolay N, Trifonov Rostislav Evgen'evich
Mendeleev Communications, 2024
5.
Current status on development of steroids as anticancer agents
Gupta A., Sathish Kumar B., Negi A.S.
Journal of Steroid Biochemistry and Molecular Biology, 2013
6.
Estradiol dimer inhibits tubulin polymerization and microtubule dynamics
Jurášek M., Černohorská M., Řehulka J., Spiwok V., Sulimenko T., Dráberová E., Darmostuk M., Gurská S., Frydrych I., Buriánová R., Ruml T., Hajdúch M., Bartůněk P., Dráber P., Džubák P., et. al.
Journal of Steroid Biochemistry and Molecular Biology, 2018
7.
Triazole-based estradiol dimers prepared via CuAAC from 17α-ethinyl estradiol with five-atom linkers causing G2/M arrest and tubulin inhibition
Jurášek M., Řehulka J., Hrubá L., Ivanová A., Gurská S., Mokshyna O., Trousil P., Huml L., Polishchuk P., Hajdúch M., Drašar P.B., Džubák P.
Bioorganic Chemistry, 2023
8.
Mono‐ and bis(steroids) containing a cyclooctane core: Synthesis, antiproliferative activity, and action on cell cytoskeleton microtubules
Ryzhikova O.V., Churkina A.S., Sedenkova K.N., Savchenkova D.V., Shakhov A.S., Lavrushkina S.V., Grishin Y.K., Zefirov N.A., Zefirova O.N., Gracheva Y.A., Milaeva E.R., Alieva I.B., Averina E.B.
Archiv der Pharmazie, 2024
10.
In Vitro Modeling of the Antitumor Drugs Effects on the Endothelial Barrier Function
Churkina A.S., Sedenkova K.N., Kovaleva P.А., Shakhov A.S., Kotlobay A.A., Averina E.B., Alieva I.B.
Archiv der Pharmazie, 2025
13.
Antivascular Actions of Microtubule-Binding Drugs
Schwartz E.L.
Clinical Cancer Research, 2009