Home / Articles / Redox-active salicylidenehydrazide analogues of vitamin E: synthesis, antioxidant and cytotoxic properties

Redox-active salicylidenehydrazide analogues of vitamin E: synthesis, antioxidant and cytotoxic properties

, 
Sofya N Klyukina 1
Sofya N Klyukina
, 
Leonid Dmitrievich Popov 2
Leonid Dmitrievich Popov
, 
Anna Anisimovna Moiseeva 1
Anna Anisimovna Moiseeva
, 
Victor Aleksandrovich Tafeenko 1
Victor Aleksandrovich Tafeenko
, 
Yulia Aleksandrovna Gracheva 1
Yulia Aleksandrovna Gracheva
, 
Dmitrii Sergeevich Yakovlev 3
Dmitrii Sergeevich Yakovlev
, 
Mariya S Pshenichnikova 3
Mariya S Pshenichnikova
, 
Alexander Alekseevich Spasov 3
Alexander Alekseevich Spasov
, 
2 Department of Chemistry, Southern Federal University, 344091 Rostov-on-Don, Russian Federation
3 Volgograd State Medical University, 400131 Volgograd, Russian Federation
10.71267/mencom.7992
Published 4 June 2026 , received 29 December 2025
Communication , Volume 36, Issue 4, 391-394
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Nikitin E. A. et al. Redox-active salicylidenehydrazide analogues of vitamin E: synthesis, antioxidant and cytotoxic properties // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 391-394.
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Nikitin E. A., Klyukina S. N., Popov L. D., Moiseeva A. A., Tafeenko V. A., Gracheva Y. A., Yakovlev D. S., Pshenichnikova M. S., Spasov A. A., Milaeva E. R. Redox-active salicylidenehydrazide analogues of vitamin E: synthesis, antioxidant and cytotoxic properties // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 391-394.
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TY - JOUR
DO - 10.71267/mencom.7992
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7992
TI - Redox-active salicylidenehydrazide analogues of vitamin E: synthesis, antioxidant and cytotoxic properties
T2 - Mendeleev Communications
AU - Nikitin, Evgeny Aleksandrovich
AU - Klyukina, Sofya N
AU - Popov, Leonid Dmitrievich
AU - Moiseeva, Anna Anisimovna
AU - Tafeenko, Victor Aleksandrovich
AU - Gracheva, Yulia Aleksandrovna
AU - Yakovlev, Dmitrii Sergeevich
AU - Pshenichnikova, Mariya S
AU - Spasov, Alexander Alekseevich
AU - Milaeva, Elena Rudol'fovna
PY - 2026
DA - 2026/06/04
PB - Mendeleev Communications
SP - 391-394
IS - 4
VL - 36
ER -
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@article{2026_Nikitin,
author = {Evgeny Aleksandrovich Nikitin and Sofya N Klyukina and Leonid Dmitrievich Popov and Anna Anisimovna Moiseeva and Victor Aleksandrovich Tafeenko and Yulia Aleksandrovna Gracheva and Dmitrii Sergeevich Yakovlev and Mariya S Pshenichnikova and Alexander Alekseevich Spasov and Elena Rudol'fovna Milaeva},
title = {Redox-active salicylidenehydrazide analogues of vitamin E: synthesis, antioxidant and cytotoxic properties},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7992},
number = {4},
pages = {391--394},
doi = {10.71267/mencom.7992}
}
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Nikitin, Evgeny Aleksandrovich, et al. “Redox-active salicylidenehydrazide analogues of vitamin E: synthesis, antioxidant and cytotoxic properties.” Mendeleev Communications, vol. 36, no. 4, Jun. 2026, pp. 391-394. https://mendcomm.colab.ws/publications/10.71267/mencom.7992.
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Keywords

antioxidants
cyclic voltammetry
cytotoxicity
electrochemistry
hydrazides
hydrazones
radioprotectors
Trolox
vitamin E

Abstract

New vitamin E hydrazone analogues bearing (2-hydroxyaryl) methylene moieties were obtained from Trolox hydrazide and the corresponding 2-hydroxyarenecarbaldehydes. The compounds demonstrated effective antioxidant activity and selective action against cancer cells, suggesting their potential as supportive pharmacological agents in oncology.

Funders

Russian Science Foundation
25-73-00106
Ministry of Education and Science of the Russian Federation
1832-2011

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