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Antitumor and antibacterial activity of novel menthyl- and bornyl-substituted 2-hydroxypropylphosphonium and arsonium salts

, 
Andrey Vladimirovich Nemtarev 1, 2
Andrey Vladimirovich Nemtarev
, 
Alexandra Dmitrievna Voloshina 2
Alexandra Dmitrievna Voloshina
, 
Anna Pavlovna Lyubina 2
Anna Pavlovna Lyubina
, 
10.71267/mencom.7986
Published 4 June 2026 , received 17 December 2025
Communication , Volume 36, Issue 4, 388-390
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Titov E. A. et al. Antitumor and antibacterial activity of novel menthyl- and bornyl-substituted 2-hydroxypropylphosphonium and arsonium salts // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 388-390.
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Titov E. A., Nemtarev A. V., Voloshina A. D., Lyubina A. P., Mironov V. F. Antitumor and antibacterial activity of novel menthyl- and bornyl-substituted 2-hydroxypropylphosphonium and arsonium salts // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 388-390.
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TY - JOUR
DO - 10.71267/mencom.7986
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7986
TI - Antitumor and antibacterial activity of novel menthyl- and bornyl-substituted 2-hydroxypropylphosphonium and arsonium salts
T2 - Mendeleev Communications
AU - Titov, Evgenii A
AU - Nemtarev, Andrey Vladimirovich
AU - Voloshina, Alexandra Dmitrievna
AU - Lyubina, Anna Pavlovna
AU - Mironov, Vladimir Fedorovich
PY - 2026
DA - 2026/06/04
PB - Mendeleev Communications
SP - 388-390
IS - 4
VL - 36
ER -
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@article{2026_Titov,
author = {Evgenii A Titov and Andrey Vladimirovich Nemtarev and Alexandra Dmitrievna Voloshina and Anna Pavlovna Lyubina and Vladimir Fedorovich Mironov},
title = {Antitumor and antibacterial activity of novel menthyl- and bornyl-substituted 2-hydroxypropylphosphonium and arsonium salts},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7986},
number = {4},
pages = {388--390},
doi = {10.71267/mencom.7986}
}
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Titov, Evgenii A., et al. “Antitumor and antibacterial activity of novel menthyl- and bornyl-substituted 2-hydroxypropylphosphonium and arsonium salts.” Mendeleev Communications, vol. 36, no. 4, Jun. 2026, pp. 388-390. https://mendcomm.colab.ws/publications/10.71267/mencom.7986.
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Keywords

antimicrobial activity
antitumor activity
arsonium salts
borneol
glycidyl ethers
menthol
phosphonium salts

Abstract

The reaction of (–)-menthyl/(–)-bornyl glycidyl ethers with H-triphenylphosphonium or H-triphenylarsonium triflates proceeds as a regioselective oxirane-opening at the terminal CH2 fragment with the formation of the corresponding 2-hydroxy-3-terpenyloxypropylphosphonium or arsonium triflates. The salts thus prepared demonstrate high antimicrobial (MIC 1.9–3.9 μM S. aureus) and antitumor (IC50 0.1–1.1 μM HuTu 80) activities.

Funders

Ministry of Education and Science of the Russian Federation
FZSM-2023-0018

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