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Synthesis of phosphorus-containing proline analogs and assessment of their antitumor activity

Nikita A Sidlyaruk 1
Nikita A Sidlyaruk
, 
Andrey Vladimirovich Smolobochkin 1
Andrey Vladimirovich Smolobochkin
,  , 
Nurgali Ikramovich Akylbekov 2
Nurgali Ikramovich Akylbekov
, 
Alena Vladimirovna Zalaltdinova 1
Alena Vladimirovna Zalaltdinova
, 
Tanzilya S Rizbayeva 1
Tanzilya S Rizbayeva
, 
Anna Pavlovna Lyubina 1
Anna Pavlovna Lyubina
, 
1 Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, 420088 Kazan, Russian Federation
2 Institute of Engineering and Technology, Korkyt Ata Kyzylorda University, 120014 Kyzylorda, Kazakhstan
10.71267/mencom.7980
Published 4 June 2026 , received 8 December 2025
Communication , Volume 36, Issue 4, 398-399
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Sidlyaruk N. A. et al. Synthesis of phosphorus-containing proline analogs and assessment of their antitumor activity // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 398-399.
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Sidlyaruk N. A., Smolobochkin A. V., Gazizov A. S., Akylbekov N. I., Zalaltdinova A. V., Rizbayeva T. S., Lyubina A. P., Burilov A. R. Synthesis of phosphorus-containing proline analogs and assessment of their antitumor activity // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 398-399.
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TY - JOUR
DO - 10.71267/mencom.7980
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7980
TI - Synthesis of phosphorus-containing proline analogs and assessment of their antitumor activity
T2 - Mendeleev Communications
AU - Sidlyaruk, Nikita A
AU - Smolobochkin, Andrey Vladimirovich
AU - Gazizov, Almir Sabirovich
AU - Akylbekov, Nurgali Ikramovich
AU - Zalaltdinova, Alena Vladimirovna
AU - Rizbayeva, Tanzilya S
AU - Lyubina, Anna Pavlovna
AU - Burilov, Alexander Romanovich
PY - 2026
DA - 2026/06/04
PB - Mendeleev Communications
SP - 398-399
IS - 4
VL - 36
ER -
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@article{2026_Sidlyaruk,
author = {Nikita A Sidlyaruk and Andrey Vladimirovich Smolobochkin and Almir Sabirovich Gazizov and Nurgali Ikramovich Akylbekov and Alena Vladimirovna Zalaltdinova and Tanzilya S Rizbayeva and Anna Pavlovna Lyubina and Alexander Romanovich Burilov},
title = {Synthesis of phosphorus-containing proline analogs and assessment of their antitumor activity},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7980},
number = {4},
pages = {398--399},
doi = {10.71267/mencom.7980}
}
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Sidlyaruk, Nikita A., et al. “Synthesis of phosphorus-containing proline analogs and assessment of their antitumor activity.” Mendeleev Communications, vol. 36, no. 4, Jun. 2026, pp. 398-399. https://mendcomm.colab.ws/publications/10.71267/mencom.7980.
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Keywords

3-arylidene-1-pyrroline
antitumor activity
proline phosphoryl analogs
Pudovik reaction
α-amino phosphonic acids

Abstract

The Pudovik reactions of 3-arylidene-1-pyrrolinium tri fluoroacetates with hydrophosphoryl compounds in benzene at room temperature for 30 min afford phosphoryl containing proline analogs. The in vitro cytotoxicity studies indicate that the obtained compounds selectively inhibit HuTu 80 tumor cells growth and the activity of some of them is comparable to that of reference 5-fluorouracil.

Funders

Ministry of Education and Science of the Russian Federation
Ministry of Education and Science of the Republic of Kazakhstan
AP23487716

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