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Carboxymethylcellulose microgels with Bi3+ and Ru3+ for medical applications

Marina Alekseevna Orlova 1
Marina Alekseevna Orlova
, 
Vasily Vladimirovich Spiridonov 1
Vasily Vladimirovich Spiridonov
, 
Vladislav Yu Yaryshev 1
Vladislav Yu Yaryshev
, 
Artem A Evdokimov 1
Artem A Evdokimov
, 
Alexander Valer'evich Severin 1
Alexander Valer'evich Severin
,  , 
Aleksandr Anatol'evich Yaroslavov 1
Aleksandr Anatol'evich Yaroslavov
, 
10.71267/mencom.7972
Published 4 June 2026 , received 20 November 2025
Communication , Volume 36, Issue 4, 376-378
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Orlova M. A. et al. Carboxymethylcellulose microgels with Bi3+ and Ru3+ for medical applications // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 376-378.
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Orlova M. A., Spiridonov V. V., Yaryshev V. Yu., Evdokimov A. A., Severin A. V., Trofimova T. P., Yaroslavov A. A., Kalmykov S. N. Carboxymethylcellulose microgels with Bi3+ and Ru3+ for medical applications // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 376-378.
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TY - JOUR
DO - 10.71267/mencom.7972
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7972
TI - Carboxymethylcellulose microgels with Bi3+ and Ru3+ for medical applications
T2 - Mendeleev Communications
AU - Orlova, Marina Alekseevna
AU - Spiridonov, Vasily Vladimirovich
AU - Yaryshev, Vladislav Yu
AU - Evdokimov, Artem A
AU - Severin, Alexander Valer'evich
AU - Trofimova, Tatiana Petrovna
AU - Yaroslavov, Aleksandr Anatol'evich
AU - Kalmykov, Stepan Nikolaevich
PY - 2026
DA - 2026/06/04
PB - Mendeleev Communications
SP - 376-378
IS - 4
VL - 36
ER -
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@article{2026_Orlova,
author = {Marina Alekseevna Orlova and Vasily Vladimirovich Spiridonov and Vladislav Yu Yaryshev and Artem A Evdokimov and Alexander Valer'evich Severin and Tatiana Petrovna Trofimova and Aleksandr Anatol'evich Yaroslavov and Stepan Nikolaevich Kalmykov},
title = {Carboxymethylcellulose microgels with Bi3+ and Ru3+ for medical applications},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7972},
number = {4},
pages = {376--378},
doi = {10.71267/mencom.7972}
}
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Orlova, Marina Alekseevna, et al. “Carboxymethylcellulose microgels with Bi3+ and Ru3+ for medical applications.” Mendeleev Communications, vol. 36, no. 4, Jun. 2026, pp. 376-378. https://mendcomm.colab.ws/publications/10.71267/mencom.7972.
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Keywords

N-(4-isopropylphenyl)-N-(1-iminoethyl)piperidine-1-carbothioamide hydrobromide
2-aminopyrimidine
Bismuth
carboxymethylcellulose
ruthenium

Abstract

The possibility of using carboxymethylcellulose as a platform for transporting ruthenium or bismuth ions in the body along with a medicinal preparation (a thiourea-derived NO synthase activator) was examined. Carboxymethylcellulose microgels were obtained by cross-linking with ruthenium or bismuth ions in a biological environment, and differences in their physicochemical parameters were identified. Furthermore, it was found that the size and aggregation stability of the microgels depend on the amount of the introduced organic ligand-drug.

Funders

Ministry of Education and Science of the Russian Federation
122012600116-4

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