Home / Articles / Electrostatic and conformational analysis of piracetam and cyclo-L-prolylglycine to explain their potency difference

Electrostatic and conformational analysis of piracetam and cyclo-L-prolylglycine to explain their potency difference

, 
Arslan Ramilevich Shaimardanov 1
Arslan Ramilevich Shaimardanov
, 
Georgy A Polovinkin 1
Georgy A Polovinkin
, 
Vitaly S Frolov 1
Vitaly S Frolov
, 
Vladimir Alexandrovich Palyulin 1
Vladimir Alexandrovich Palyulin
10.71267/mencom.7968
Published 4 June 2026 , received 10 November 2025
Communication , Volume 36, Issue 4, 379-381
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Shulga D. A. et al. Electrostatic and conformational analysis of piracetam and cyclo-L-prolylglycine to explain their potency difference // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 379-381.
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Shulga D. A., Shaimardanov A. R., Polovinkin G. A., Frolov V. S., Palyulin V. A. Electrostatic and conformational analysis of piracetam and cyclo-L-prolylglycine to explain their potency difference // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 379-381.
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TY - JOUR
DO - 10.71267/mencom.7968
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7968
TI - Electrostatic and conformational analysis of piracetam and cyclo-L-prolylglycine to explain their potency difference
T2 - Mendeleev Communications
AU - Shulga, Dmitry Alexandrovich
AU - Shaimardanov, Arslan Ramilevich
AU - Polovinkin, Georgy A
AU - Frolov, Vitaly S
AU - Palyulin, Vladimir Alexandrovich
PY - 2026
DA - 2026/06/04
PB - Mendeleev Communications
SP - 379-381
IS - 4
VL - 36
ER -
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@article{2026_Shulga,
author = {Dmitry Alexandrovich Shulga and Arslan Ramilevich Shaimardanov and Georgy A Polovinkin and Vitaly S Frolov and Vladimir Alexandrovich Palyulin},
title = {Electrostatic and conformational analysis of piracetam and cyclo-L-prolylglycine to explain their potency difference},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7968},
number = {4},
pages = {379--381},
doi = {10.71267/mencom.7968}
}
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Shulga, Dmitry Alexandrovich, et al. “Electrostatic and conformational analysis of piracetam and cyclo-L-prolylglycine to explain their potency difference.” Mendeleev Communications, vol. 36, no. 4, Jun. 2026, pp. 379-381. https://mendcomm.colab.ws/publications/10.71267/mencom.7968.
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Keywords

conformational analysis
cyclo-L-prolylglycine
molecular electrostatic potential
nootropic drugs
piracetam

Abstract

The molecular electrostatic potential of the classical nootropic drug piracetam in several of its probable conformations was shown to resemble that of the neuropeptide cyclo-L-prolylglycine in its rigidly fixed conformation. Furthermore, the probability of observing this specific conformation was found to be close to the activity ratio of piracetam to cyclo-L-prolylglycine. These results support the previously proposed hypothesis that cyclo-L-prolylglycine is an endogenous analog of piracetam.

Funders

Ministry of Education and Science of the Russian Federation
121021000105-7

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