Home / Articles / Design and synthesis of spiro-linked azacycloalkane--dihydropyrano[4,3-d]pyrimidine compounds

Design and synthesis of spiro-linked azacycloalkane--dihydropyrano[4,3-d]pyrimidine compounds

Maxim E. Zhuravlev 1
Maxim E. Zhuravlev
, 
Kristina Yuryevna Komarova 1
Kristina Yuryevna Komarova
, 
Lyubov V Khudiakova 1
Lyubov V Khudiakova
, 
Mikhail Vasil'evich Chudinov 1
Mikhail Vasil'evich Chudinov
, 
Alexei Yur'evich Lukin 1
Alexei Yur'evich Lukin
, 
Dmitry Viktorovich Dar’in 2
Dmitry Viktorovich Dar’in
1 M. V. Lomonosov Institute of Fine Chemical Technologies, MIREA -- Russian Technological University, 119454 Moscow, Russian Federation
2 St. Petersburg State University, 198504 St. Petersburg, Russian Federation
10.71267/mencom.7965
Published 4 June 2026 , received 7 November 2025
Communication , Volume 36, Issue 4, 455-456
0
Share
Cite this
GOST
 | 
Cite this
GOST
Copy cite
Zhuravlev M. E. et al. Design and synthesis of spiro-linked azacycloalkane--dihydropyrano[4,3-d]pyrimidine compounds // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 455-456.
GOST all authors (up to 50)
Copy cite
Zhuravlev M. E., Komarova K. Y., Khudiakova L. V., Chudinov M. V., Lukin A. Y., Dar’in D. V. Design and synthesis of spiro-linked azacycloalkane--dihydropyrano[4,3-d]pyrimidine compounds // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 455-456.
RIS
 | 
Cite this
RIS
Copy cite
TY - JOUR
DO - 10.71267/mencom.7965
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7965
TI - Design and synthesis of spiro-linked azacycloalkane--dihydropyrano[4,3-d]pyrimidine compounds
T2 - Mendeleev Communications
AU - Zhuravlev, Maxim E.
AU - Komarova, Kristina Yuryevna
AU - Khudiakova, Lyubov V
AU - Chudinov, Mikhail Vasil'evich
AU - Lukin, Alexei Yur'evich
AU - Dar’in, Dmitry Viktorovich
PY - 2026
DA - 2026/06/04
PB - Mendeleev Communications
SP - 455-456
IS - 4
VL - 36
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors)
Copy cite
@article{2026_Zhuravlev,
author = {Maxim E. Zhuravlev and Kristina Yuryevna Komarova and Lyubov V Khudiakova and Mikhail Vasil'evich Chudinov and Alexei Yur'evich Lukin and Dmitry Viktorovich Dar’in},
title = {Design and synthesis of spiro-linked azacycloalkane--dihydropyrano[4,3-d]pyrimidine compounds},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7965},
number = {4},
pages = {455--456},
doi = {10.71267/mencom.7965}
}
MLA
Cite this
MLA
Copy cite
Zhuravlev, Maxim E., et al. “Design and synthesis of spiro-linked azacycloalkane--dihydropyrano[4,3-d]pyrimidine compounds.” Mendeleev Communications, vol. 36, no. 4, Jun. 2026, pp. 455-456. https://mendcomm.colab.ws/publications/10.71267/mencom.7965.
Views / Visits
22 / 22

Keywords

drug design
pyrano[4,3-d]pyrimidine
pyrimidine synthesis
regiospecificity
spiro compounds

Abstract

New dihydropyrano[4,3-d]pyrimidines bearing 7-positioned spiro-linked azacycloalkane moieties were obtained by the Prins spirocyclization of commercially available N-protected azacycloalkanones followed by the regiospecific condensation with dimethylformamide dimethyl acetal and amidines. The new scaffold thus accessed appears to be a valuable building block for drug development.

Funders

Ministry of Education and Science of the Russian Federation
FSFZ-2026-0007

References

1.
Privileged scaffolds in lead generation
Zhao H., Dietrich J.
Expert Opinion on Drug Discovery, 2015
3.
ref-10.71267-mendc7458-1-3-1-0
X. Wang, A. Ivetac, S. Kulyk, J. D. Lawson, M. A. Marx and C. R. Smith
2023
4.
ref-10.71267-mendc7458-1-4-1-0
S. Trah, L. Quaranta, C. Lamberth and M. Pouliot
2012
5.
ref-10.71267-mendc7458-1-5-1-0
T. J. Senter, M. Chen, L. A. Dakin, Z. Gale-Day, S. Namirembe, J. H. Olsen, A. J. Shimizu, H. Wang and T. Wang
2023
6.
ref-10.71267-mendc7458-1-6-1-0
J. McCartney, A. R. Abela, S. Abraham, C. D. Anderson, V. Arumugam, J. Chau, J. Clemens, T. Cleveland, T. R. Coon, T. A. Dwight, L. T. D. Fanning, B. A. Frieman, A. V. Gulevich, S. S. Hadida Ruah, Y. Ishihara, et. al.
2022
7.
ref-10.71267-mendc7458-1-7-1-0
W. Grammenos, T. Grote, J. Dietz, J. K. Lohmann, J. Renner, B. Mueller and S. Ulmschneider
2007
8.
Spirocyclic Scaffolds in Medicinal Chemistry
Hiesinger K., Dar’in D., Proschak E., Krasavin M.
Journal of Medicinal Chemistry, 2020
9.
Fsp3: A new parameter for drug-likeness
Wei W., Cherukupalli S., Jing L., Liu X., Zhan P.
Drug Discovery Today, 2020
10.
Spirocyclic compounds: potential drug leads in the fight against Mycobacterium tuberculosis
Kumar P., Singampalli A., Bandela R., Srimounika B., Rajyalakshmi S.I., Devi A., Nanduri S., Venkata Madhavi Y.
Future Medicinal Chemistry, 2025
11.
Lukin Alexei Yur'evich, Vinogradova Lyubov V, Komarova Kristina Yuryevna, Krasavin Mikhail Yur'evich
Mendeleev Communications, 2023
12.
The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against M. tuberculosis
Komarova K., Vinogradova L., Lukin A., Zhuravlev M., Deniskin D., Chudinov M., Gureev M., Dogonadze M., Zabolotnykh N., Vinogradova T., Lavrova A., Yablonskiy P.
Molecules, 2024
13.
Recent Developments in Prins Cyclization Towards the Synthesis of Spirocyclic Scaffolds
Saikia A.K., Biswas S., Porashar B., Deka M.J.
Asian Journal of Organic Chemistry, 2025
14.
Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid
Lukin A., Bagnyukova D., Kalinchenkova N., Zhurilo N., Krasavin M.
Tetrahedron Letters, 2016