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Synthesis of novel antibiofilm kojic acid-based bis-pyridinium salts

Nikita Andreevich Frolov 1
Nikita Andreevich Frolov
, 
Mary A Seferyan 1
Mary A Seferyan
, 
Anver B Valeev 1, 2
Anver B Valeev
, 
Andrey D Vinokurov 1
Andrey D Vinokurov
, 
Artemiy Sychyov 1, 3
Artemiy Sychyov
, 
Elena Vladimirovna Detusheva 1, 4
Elena Vladimirovna Detusheva
, 
Anatoly Nikolaevich Vereshchagin 1
Anatoly Nikolaevich Vereshchagin
2 Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation
4 State Research Center for Applied Microbiology & Biotechnology, 142279 Obolensk, Moscow Region, Russian Federation
10.71267/mencom.7940
Published 4 June 2026 , received 14 October 2025
Communication , Volume 36, Issue 4, 395-397
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Frolov N. A. et al. Synthesis of novel antibiofilm kojic acid-based bis-pyridinium salts // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 395-397.
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Frolov N. A., Seferyan M. A., Valeev A. B., Vinokurov A. D., Sychyov A., Detusheva E. V., Vereshchagin A. N. Synthesis of novel antibiofilm kojic acid-based bis-pyridinium salts // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 395-397.
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TY - JOUR
DO - 10.71267/mencom.7940
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7940
TI - Synthesis of novel antibiofilm kojic acid-based bis-pyridinium salts
T2 - Mendeleev Communications
AU - Frolov, Nikita Andreevich
AU - Seferyan, Mary A
AU - Valeev, Anver B
AU - Vinokurov, Andrey D
AU - Sychyov, Artemiy
AU - Detusheva, Elena Vladimirovna
AU - Vereshchagin, Anatoly Nikolaevich
PY - 2026
DA - 2026/06/04
PB - Mendeleev Communications
SP - 395-397
IS - 4
VL - 36
ER -
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@article{2026_Frolov,
author = {Nikita Andreevich Frolov and Mary A Seferyan and Anver B Valeev and Andrey D Vinokurov and Artemiy Sychyov and Elena Vladimirovna Detusheva and Anatoly Nikolaevich Vereshchagin},
title = {Synthesis of novel antibiofilm kojic acid-based bis-pyridinium salts},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7940},
number = {4},
pages = {395--397},
doi = {10.71267/mencom.7940}
}
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Frolov, Nikita Andreevich, et al. “Synthesis of novel antibiofilm kojic acid-based bis-pyridinium salts.” Mendeleev Communications, vol. 36, no. 4, Jun. 2026, pp. 395-397. https://mendcomm.colab.ws/publications/10.71267/mencom.7940.
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Keywords

antibacterial agents
biofilms
bis-quaternary ammonium compounds
ESKAPE pathogens
kojic acid
pyridinium salts

Abstract

Six novel 1,3-disubstituted bis-pyridinium compounds containing two kojic acid fragments in the linker were synthesized via three simple steps from kojic acid, 1,4-di-bromobutane and 3-(alkylamino)pyridines. An assessment of the bacteriostatic and bactericidal potential of the obtained compounds against reference and clinical strains of ESKAPE pathogens showed their ability to inhibit the growth and to destroy mature biofilms of Gram-positive and Gram-negative bacteria.

Funders

Russian Science Foundation
24-13-00307

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