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Direct synthesis and cytotoxic activity of new macrodiolides with 2,5-disubstituted tetrahydrofuran moieties

Ilgiz Ilshatovich Islamov 1
Ilgiz Ilshatovich Islamov
, 
Aleksey Aleksandrovich Makarov 1
Aleksey Aleksandrovich Makarov
, 
Ilgam Vaisovich Gajsin 1
Ilgam Vaisovich Gajsin
, 
Lilya Useinovna Dzhemileva 2
Lilya Useinovna Dzhemileva
,  , 
Vladimir Anatol'evich D'yakonov 2
Vladimir Anatol'evich D'yakonov
10.71267/mencom.7923
Published 4 June 2026 , received 23 September 2025
Communication , Volume 36, Issue 4, 385-387
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Islamov I. I. et al. Direct synthesis and cytotoxic activity of new macrodiolides with 2,5-disubstituted tetrahydrofuran moieties // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 385-387.
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Islamov I. I., Makarov A. A., Gajsin I. V., Dzhemileva L. U., Dzhemilev U. M., D'yakonov V. A. Direct synthesis and cytotoxic activity of new macrodiolides with 2,5-disubstituted tetrahydrofuran moieties // Mendeleev Communications. 2026. Vol. 36. No. 4. pp. 385-387.
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TY - JOUR
DO - 10.71267/mencom.7923
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7923
TI - Direct synthesis and cytotoxic activity of new macrodiolides with 2,5-disubstituted tetrahydrofuran moieties
T2 - Mendeleev Communications
AU - Islamov, Ilgiz Ilshatovich
AU - Makarov, Aleksey Aleksandrovich
AU - Gajsin, Ilgam Vaisovich
AU - Dzhemileva, Lilya Useinovna
AU - Dzhemilev, Usein Memetovich
AU - D'yakonov, Vladimir Anatol'evich
PY - 2026
DA - 2026/06/04
PB - Mendeleev Communications
SP - 385-387
IS - 4
VL - 36
ER -
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@article{2026_Islamov,
author = {Ilgiz Ilshatovich Islamov and Aleksey Aleksandrovich Makarov and Ilgam Vaisovich Gajsin and Lilya Useinovna Dzhemileva and Usein Memetovich Dzhemilev and Vladimir Anatol'evich D'yakonov},
title = {Direct synthesis and cytotoxic activity of new macrodiolides with 2,5-disubstituted tetrahydrofuran moieties},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7923},
number = {4},
pages = {385--387},
doi = {10.71267/mencom.7923}
}
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Islamov, Ilgiz Ilshatovich, et al. “Direct synthesis and cytotoxic activity of new macrodiolides with 2,5-disubstituted tetrahydrofuran moieties.” Mendeleev Communications, vol. 36, no. 4, Jun. 2026, pp. 385-387. https://mendcomm.colab.ws/publications/10.71267/mencom.7923.
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Keywords

1,2-dienes
1Z,5Z-1,5-dienes
cytotoxicity
homo-cyclomagnesiation
macrodiolides
substituted tetrahydrofurans

Abstract

A novel strategy for synthesizing new polyfunctional macrodiolides based on the oxidative cyclization of (1Z,5Z)-diene bonds to form 2,5-disubstituted tetrahydrofurans has been developed. The unsaturated macrodiolide was obtained using an original catalytic homo-cyclomagnesiation of O-containing 1,2-dienes (the Dzhemilev reaction). The macrocyclic compounds demonstrated cytotoxic activity in tests on Jurkat, A549, and HEK293 cell lines.

Funders

Ministry of Education and Science of the Russian Federation
FMRS-2025-0047

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