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Production of medical radionuclide 44Sc from 44Ti by extraction with organophosphorus compounds

Nikolay Andreevich Titchenko 1, 2
Nikolay Andreevich Titchenko
, 
Stanislav Viktorovich Ermolaev 2
Stanislav Viktorovich Ermolaev
, 
Elena A. Perekina 1, 2
Elena A. Perekina
, 
Bayirta Vladimirovna Egorova 1
Bayirta Vladimirovna Egorova
, 
Stepan Nikolaevich Kalmykov 1, 3
Stepan Nikolaevich Kalmykov
10.71267/mencom.7916
Published 2026-02-03
Communication , Volume 36, Issue 2, 155-157
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Titchenko N. A. et al. Production of medical radionuclide 44Sc from 44Ti by extraction with organophosphorus compounds // Mendeleev Communications. 2026. Vol. 36. No. 2. pp. 155-157.
GOST all authors (up to 50) Copy
Titchenko N. A., Ermolaev S. V., Perekina E. A., Egorova B. V., Kalmykov S. N. Production of medical radionuclide 44Sc from 44Ti by extraction with organophosphorus compounds // Mendeleev Communications. 2026. Vol. 36. No. 2. pp. 155-157.
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TY - JOUR
DO - 10.71267/mencom.7916
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7916
TI - Production of medical radionuclide 44Sc from 44Ti by extraction with organophosphorus compounds
T2 - Mendeleev Communications
AU - Titchenko, Nikolay Andreevich
AU - Ermolaev, Stanislav Viktorovich
AU - Perekina, Elena A.
AU - Egorova, Bayirta Vladimirovna
AU - Kalmykov, Stepan Nikolaevich
PY - 2026
DA - 2026/02/03
PB - Mendeleev Communications
SP - 155-157
IS - 2
VL - 36
ER -
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@article{2026_Titchenko,
author = {Nikolay Andreevich Titchenko and Stanislav Viktorovich Ermolaev and Elena A. Perekina and Bayirta Vladimirovna Egorova and Stepan Nikolaevich Kalmykov},
title = {Production of medical radionuclide 44Sc from 44Ti by extraction with organophosphorus compounds},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7916},
number = {2},
pages = {155--157},
doi = {10.71267/mencom.7916}
}
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Titchenko, Nikolay Andreevich, et al. “Production of medical radionuclide 44Sc from 44Ti by extraction with organophosphorus compounds.” Mendeleev Communications, vol. 36, no. 2, Feb. 2026, pp. 155-157. https://mendcomm.colab.ws/publications/10.71267/mencom.7916.
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Keywords

44Ti/44Sc generator
extraction
organophosphorus compounds
positron-emission tomography
TBP
TOPO

Abstract

Extraction systems based on organophosphorus compounds (DEHPA, TBP, and TOPO) in HCl and HNO3 were studied for developing a reverse 44Ti/44Sc generator. The 1.8 M TBP–7 M HCl and 0.18 M TOPO–3 M HCl systems demonstrated high separation efficiency in a multistage process and provided 44Sc extraction yields of 96.4 and 93.6% with 44Ti impurities of 8.5 × 10–3 and 1.8 ×10–2%, respectively. The daughter 44Sc was quantitatively back-extracted into dilute HCl, providing a ready-to-use solution for subsequent labeling.

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