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Development and examination of self-assembled nanoformulation of biotinylated paclitaxel derivative

Dmitry Vladimirovich Beigulenko 1
Dmitry Vladimirovich Beigulenko
, 
Ekaterina S Kazakova 1
Ekaterina S Kazakova
,  , 
Konstantin Aleksandrovich Kochetkov 2
Konstantin Aleksandrovich Kochetkov
10.71267/mencom.7913
Published 2026-03-24
Communication , Volume 36, Issue 3, 298-300
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Beigulenko D. V. et al. Development and examination of self-assembled nanoformulation of biotinylated paclitaxel derivative // Mendeleev Communications. 2026. Vol. 36. No. 3. pp. 298-300.
GOST all authors (up to 50) Copy
Beigulenko D. V., Kazakova E. S., Kovshova T. S., Kochetkov K. A. Development and examination of self-assembled nanoformulation of biotinylated paclitaxel derivative // Mendeleev Communications. 2026. Vol. 36. No. 3. pp. 298-300.
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TY - JOUR
DO - 10.71267/mencom.7913
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7913
TI - Development and examination of self-assembled nanoformulation of biotinylated paclitaxel derivative
T2 - Mendeleev Communications
AU - Beigulenko, Dmitry Vladimirovich
AU - Kazakova, Ekaterina S
AU - Kovshova, Tatyana Sergeevna
AU - Kochetkov, Konstantin Aleksandrovich
PY - 2026
DA - 2026/03/24
PB - Mendeleev Communications
SP - 298-300
IS - 3
VL - 36
ER -
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@article{2026_Beigulenko,
author = {Dmitry Vladimirovich Beigulenko and Ekaterina S Kazakova and Tatyana Sergeevna Kovshova and Konstantin Aleksandrovich Kochetkov},
title = {Development and examination of self-assembled nanoformulation of biotinylated paclitaxel derivative},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7913},
number = {3},
pages = {298--300},
doi = {10.71267/mencom.7913}
}
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Beigulenko, Dmitry Vladimirovich, et al. “Development and examination of self-assembled nanoformulation of biotinylated paclitaxel derivative.” Mendeleev Communications, vol. 36, no. 3, Mar. 2026, pp. 298-300. https://mendcomm.colab.ws/publications/10.71267/mencom.7913.
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Keywords

biotin
conjugate
drug delivery
nanoformulation
nanoparticle
paclitaxel
self-assembled nanostructures

Abstract

The attachment of biotin to paclitaxel resulted in a conjugate capable of self-assembling under optimal conditions into spherical nanoparticles with a favorable size distribution and colloidal stability. These nanostructures specifically bind to the model receptor avidin, confirming their potential for both active and passive tumor targeting. Due to their low hemolytic activity, the conjugate nanoparticles can be considered a promising nanoformulation for paclitaxel delivery systems.

Funders

Russian Science Foundation
25-73-00018

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