Home / Publications / Coordination-driven self-assembly of pentacopper metallamacrocycles with N-(3-hydroxy-2-methyl-4-oxopyridin-1-yl)isonicotinamide units for antimycobacterial activity

Coordination-driven self-assembly of pentacopper metallamacrocycles with N-(3-hydroxy-2-methyl-4-oxopyridin-1-yl)isonicotinamide units for antimycobacterial activity

,  ,  ,  ,  , 
Grigory Yu Zhigulin 1
Grigory Yu Zhigulin
,  , 
10.71267/mencom.7874
Published 2025-11-29
Communication , Volume 36, Issue 1, 21-24
0
Share
Cite this
GOST
 | 
Cite this
GOST Copy
Katkova M. A. et al. Coordination-driven self-assembly of pentacopper metallamacrocycles with N-(3-hydroxy-2-methyl-4-oxopyridin-1-yl)isonicotinamide units for antimycobacterial activity // Mendeleev Communications. 2025. Vol. 36. No. 1. pp. 21-24.
GOST all authors (up to 50) Copy
Katkova M. A., Rumyantcev R. V., Zabrodina G. S., Fomina I. G., Bekker O. B., Zhigulin G. Yu., Ketkov S. Y., Eremenko I. L. Coordination-driven self-assembly of pentacopper metallamacrocycles with N-(3-hydroxy-2-methyl-4-oxopyridin-1-yl)isonicotinamide units for antimycobacterial activity // Mendeleev Communications. 2025. Vol. 36. No. 1. pp. 21-24.
RIS
 | 
Cite this
RIS Copy
TY - JOUR
DO - 10.71267/mencom.7874
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7874
TI - Coordination-driven self-assembly of pentacopper metallamacrocycles with N-(3-hydroxy-2-methyl-4-oxopyridin-1-yl)isonicotinamide units for antimycobacterial activity
T2 - Mendeleev Communications
AU - Katkova, Marina Aleksandrovna
AU - Rumyantcev, Roman Valeryevich
AU - Zabrodina, Galina Sergeevna
AU - Fomina, Irina Georgievna
AU - Bekker, Olga B
AU - Zhigulin, Grigory Yu
AU - Ketkov, Sergei Yulievich
AU - Eremenko, Igor Leonidovich
PY - 2025
DA - 2025/11/29
PB - Mendeleev Communications
SP - 21-24
IS - 1
VL - 36
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Katkova,
author = {Marina Aleksandrovna Katkova and Roman Valeryevich Rumyantcev and Galina Sergeevna Zabrodina and Irina Georgievna Fomina and Olga B Bekker and Grigory Yu Zhigulin and Sergei Yulievich Ketkov and Igor Leonidovich Eremenko},
title = {Coordination-driven self-assembly of pentacopper metallamacrocycles with N-(3-hydroxy-2-methyl-4-oxopyridin-1-yl)isonicotinamide units for antimycobacterial activity},
journal = {Mendeleev Communications},
year = {2025},
volume = {36},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7874},
number = {1},
pages = {21--24},
doi = {10.71267/mencom.7874}
}
MLA
Cite this
MLA Copy
Katkova, Marina Aleksandrovna, et al. “Coordination-driven self-assembly of pentacopper metallamacrocycles with N-(3-hydroxy-2-methyl-4-oxopyridin-1-yl)isonicotinamide units for antimycobacterial activity.” Mendeleev Communications, vol. 36, no. 1, Nov. 2025, pp. 21-24. https://mendcomm.colab.ws/publications/10.71267/mencom.7874.
Views
4

Keywords

biological activity.
copper
DFT calculations
metallamacrocycle
N-(3-hydroxy-2-methyl-4-oxopyridin-1-yl)isonicotinamide
supramolecular complex
X-ray structure
β-alaninehydroximate

Abstract

A new supramolecular complex consisting of a β-alaninehydroximate metallamacrocyclic cation and a metal-organic cuprate anion was obtained and characterized using X-ray diffraction analysis and DFT calculations. The unique 3D supramolecular assembly is formed due to the system of Cu···O and Cu···N intermolecular interactions. The cuprate structure indicates delocalization of the electron density in the pyridinone-isonicotinamide fragment, which may contribute to the detected enhanced antimycobacterial activity of the complex.

Funders

Russian Science Foundation
23-13-00139

References

1.
Combatting Antibiotic Resistance Using Supramolecular Assemblies
Guo S., He Y., Zhu Y., Tang Y., Yu B.
Pharmaceuticals, 2022
3.
Metal–Organic Frameworks for Drug Delivery: A Design Perspective
Lawson H.D., Walton S.P., Chan C.
ACS applied materials & interfaces, 2021
5.
Discrete metallosupramolecular architectures with amino acids
Thoonen S., Tuck K.L., Turner D.R.
Coordination Chemistry Reviews, 2025
6.
Inter-conversion of 15-MC-5 to 12-MC-4 manganese metallacrowns: structure and bioactivity of metallacrowns hosting carboxylato complexes
Dendrinou-Samara C., Papadopoulos A.N., Malamatari D.A., Tarushi A., Raptopoulou C.P., Terzis A., Samaras E., Kessissoglou D.P.
Journal of Inorganic Biochemistry, 2005
7.
Unexpected influence of metallamacrocyclic architecture of heterometallic pyrazinehydroximate Cu(II)-Bi(III) and Cu(II)-La(III) complexes on their antibacterial activity against Mycolicibacterium smegmatis
Katkova M.A., Zabrodina G.S., Zhigulin G.Y., Rumyantsev R.V., Kiskin M.A., Fomina I.G., Bekker O.B., Ketkov S.Y., Eremenko I.L.
Inorganica Chimica Acta, 2024
8.
Noncovalent interactions: A brief account of a long history
Schneider H.
Journal of Physical Organic Chemistry, 2022
9.
Supramolecular Maleate Adducts of Copper(II) 12-Metallacrown-4: Magnetism, EPR, and Alcohol Sorption Properties
Pavlishchuk A.V., Kolotilov S.V., Zeller M., Lofland S.E., Kiskin M.A., Efimov N.N., Ugolkova E.A., Minin V.V., Novotortsev V.M., Addison A.W.
European Journal of Inorganic Chemistry, 2017
10.
Structural and Magnetic Properties of a {GdCu5}2 Metallacrown Dimer with a Disulfonate Linker
Pavlishchuk A.V., Zeller M., Carrella L.M., Rentschler E., Bindra J.K., Dalal N., Kinyon J., Perera K., Pavlishchuk V.V., Addison A.W.
European Journal of Inorganic Chemistry, 2024
12.
Katkova M.A., Zabrodina G.S., Rumyantcev R.V., Zhigulin G.Y., Skabitsky I.V., Fomina I.G., Bekker O.B., Ketkov S.Y., Eremenko I.L.
Mendeleev Communications, 2024
13.
Features of the Crystal Structure of Polynuclear Metallamacrocyclic Copper (II) Complexes Containing Polycarboxylate Anions
Zabrodina G.S., Rumyantsev R.V., Katkova M.A., Ketkov S.Y.
Journal of Structural Chemistry, 2024
15.
SHELXT– Integrated space-group and crystal-structure determination
Sheldrick G.M.
Acta Crystallographica Section A: Foundations and Advances, 2015
16.
Crystal structure refinement withSHELXL
Sheldrick G.M.
Acta crystallographica. Section C, Structural chemistry, 2015
18.
X-Ray and potentiometric studies on a pentanuclear copper(II) complex with β-alaninehydroxamic acid
Kurzak B., Farkas E., Glowiak T., Kozlowski H.
Journal of the Chemical Society Dalton Transactions, 1991
19.
FEATURES OF DICYANAMIDE BINDING TO A POLYNUCLEAR METALLAMACROCYCLIC COPPER COMPLEX
Rumyantsev R.V., Katkova M.A., Zabrodina G.S., Ketkov S.Y.
Journal of Structural Chemistry, 2023
21.
12-MC-4 metallacrowns as versatile tools for SMM research
Happ P., Plenk C., Rentschler E.
Coordination Chemistry Reviews, 2015
22.
The First Ate Complex of Copper(II) 5-Chlorosalicylhydroximate Metallacrown with Outer-Sphere Nickel(II) Cation
Zabrodina G.S., Katkova M.A., Rumyantcev R.V., Zhigulin G.Y., Ketkov S.Y.
Macroheterocycles, 2022
23.
New applications of van der Waals radii in chemistry
Zefirov Y.V., Zorky P.M.
Russian Chemical Reviews, 1995
24.
Synthesis and Molecular Structure of the First Metallamacrocyclic Bi(III)-Cu(II) 15-MC-5 Complex Derived from Pyrazinohydroxamic Acid
Zabrodina G.S., Katkova M.A., Baranov E.V., Zhigulin G.Y., Ketkov S.Y.
Macroheterocycles, 2019
25.
Quantum chemical study of formation of CuII–YIII metallamacrocyclic complexes based on glycinehydroximate ligands
Zhigulin G.Y., Zabrodina G.S., Katkova M.A., Ketkov S.Y.
Russian Chemical Bulletin, 2018
28.
Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies
Hassan N.W., Saudi M.N., Abdel-Ghany Y.S., Ismail A., Elzahhar P.A., Sriram D., Nassra R., Abdel-Aziz M.M., El-Hawash S.A.
Bioorganic Chemistry, 2020
29.
Novel Derivatives of Quinoxaline-2-carboxylic Acid 1,4-Dioxides as Antimycobacterial Agents: Mechanistic Studies and Therapeutic Potential
Frolova S.G., Vatlin A.A., Maslov D.A., Yusuf B., Buravchenko G.I., Bekker O.B., Klimina K.M., Smirnova S.V., Shnakhova L.M., Malyants I.K., Lashkin A.I., Tian X., Alam M.S., Zatonsky G.V., Zhang T., et. al.
Pharmaceuticals, 2023