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Direct modification and antimicrobial activity of L-lysyl-L-leucine and its analogues

Yulia V Kozlova 1
Yulia V Kozlova
, 
Zaret Gezimahmaevna Denieva 2
Zaret Gezimahmaevna Denieva
, 
Maria Sergeevna Zolotareva 1
Maria Sergeevna Zolotareva
, 
Ul'yana Aleksandrovna Budanova 1
Ul'yana Aleksandrovna Budanova
, 
Yurii Lvovich Sebyakin 1
Yurii Lvovich Sebyakin
10.71267/mencom.7863
Published 2026-02-03
Communication , Volume 36, Issue 2, 148-150
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Kozlova Y. V. et al. Direct modification and antimicrobial activity of L-lysyl-L-leucine and its analogues // Mendeleev Communications. 2026. Vol. 36. No. 2. pp. 148-150.
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Kozlova Y. V., Denieva Z. G., Zolotareva M. S., Budanova U. A., Sebyakin Y. L. Direct modification and antimicrobial activity of L-lysyl-L-leucine and its analogues // Mendeleev Communications. 2026. Vol. 36. No. 2. pp. 148-150.
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TY - JOUR
DO - 10.71267/mencom.7863
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7863
TI - Direct modification and antimicrobial activity of L-lysyl-L-leucine and its analogues
T2 - Mendeleev Communications
AU - Kozlova, Yulia V
AU - Denieva, Zaret Gezimahmaevna
AU - Zolotareva, Maria Sergeevna
AU - Budanova, Ul'yana Aleksandrovna
AU - Sebyakin, Yurii Lvovich
PY - 2026
DA - 2026/02/03
PB - Mendeleev Communications
SP - 148-150
IS - 2
VL - 36
ER -
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@article{2026_Kozlova,
author = {Yulia V Kozlova and Zaret Gezimahmaevna Denieva and Maria Sergeevna Zolotareva and Ul'yana Aleksandrovna Budanova and Yurii Lvovich Sebyakin},
title = {Direct modification and antimicrobial activity of L-lysyl-L-leucine and its analogues},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7863},
number = {2},
pages = {148--150},
doi = {10.71267/mencom.7863}
}
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Kozlova, Yulia V., et al. “Direct modification and antimicrobial activity of L-lysyl-L-leucine and its analogues.” Mendeleev Communications, vol. 36, no. 2, Feb. 2026, pp. 148-150. https://mendcomm.colab.ws/publications/10.71267/mencom.7863.

Keywords

Antibacterial activity
antimicrobial amphiphiles
D/L amino acids
leucine analogues
lysine
modified lipodipeptides
pore-like defects

Abstract

New cationic amphiphiles based on L-lysine and leucine C9--C12 alkyl esters (including optical isomers and structural analogues) were obtained. The influence of certain modifications in them on the antimicrobial activity was evaluated. The lead compound (hydrotrifluoroacetate of L-lysyl-L-leucine decyl ester) showed the highest efficacy with minimum inhibitory concentrations of 0.19 and 0.39 μg ml--1, which is less than that for the control antibiotics vancomycin and ampicillin.

Funders

Ministry of Education and Science of the Russian Federation
075-15- 2025-548

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