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Synthesis and antioxidant activity of apiol-derived 3-arylpropanamines

Alexander Nikolaevich Blinnikov 1
Alexander Nikolaevich Blinnikov
, 
Martha М Malibiche 1
Martha М Malibiche
, 
Olga Igorevna Adaeva 1
Olga Igorevna Adaeva
, 
Sergey S Krylov 1
Sergey S Krylov
, 
Oksana G Shevchenko 2
Oksana G Shevchenko
,  , 
M N Semenova 1
M N Semenova
, 
Victor Vladimirovich Semenov 1
Victor Vladimirovich Semenov
2 Institute of Biology, Komi Science Center, Ural Branch of the Russian Academy of Sciences, 167982 Syktyvkar, Russian Federation
10.71267/mencom.7859
Published 2026-02-03
Communication , Volume 36, Issue 2, 167-170
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Blinnikov A. N. et al. Synthesis and antioxidant activity of apiol-derived 3-arylpropanamines // Mendeleev Communications. 2026. Vol. 36. No. 2. pp. 167-170.
GOST all authors (up to 50) Copy
Blinnikov A. N., Malibiche M. М., Adaeva O. I., Krylov S. S., Shevchenko O. G., Demchuk D. V., Semenova M. N., Semenov V. V. Synthesis and antioxidant activity of apiol-derived 3-arylpropanamines // Mendeleev Communications. 2026. Vol. 36. No. 2. pp. 167-170.
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TY - JOUR
DO - 10.71267/mencom.7859
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7859
TI - Synthesis and antioxidant activity of apiol-derived 3-arylpropanamines
T2 - Mendeleev Communications
AU - Blinnikov, Alexander Nikolaevich
AU - Malibiche, Martha М
AU - Adaeva, Olga Igorevna
AU - Krylov, Sergey S
AU - Shevchenko, Oksana G
AU - Demchuk, Dmitry Valentinovich
AU - Semenova, M N
AU - Semenov, Victor Vladimirovich
PY - 2026
DA - 2026/02/03
PB - Mendeleev Communications
SP - 167-170
IS - 2
VL - 36
ER -
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@article{2026_Blinnikov,
author = {Alexander Nikolaevich Blinnikov and Martha М Malibiche and Olga Igorevna Adaeva and Sergey S Krylov and Oksana G Shevchenko and Dmitry Valentinovich Demchuk and M N Semenova and Victor Vladimirovich Semenov},
title = {Synthesis and antioxidant activity of apiol-derived 3-arylpropanamines},
journal = {Mendeleev Communications},
year = {2026},
volume = {36},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7859},
number = {2},
pages = {167--170},
doi = {10.71267/mencom.7859}
}
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Cite this
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Blinnikov, Alexander Nikolaevich, et al. “Synthesis and antioxidant activity of apiol-derived 3-arylpropanamines.” Mendeleev Communications, vol. 36, no. 2, Feb. 2026, pp. 167-170. https://mendcomm.colab.ws/publications/10.71267/mencom.7859.

Keywords

3-(methylenedioxyphenyl)propan-1-amines
antioxidant activity
apiol
neurotropic amphetamines
parsley seeds
sea urchin

Abstract

3-(2,5-Dimethoxy-3,4-methylenedioxyphenyl)propan-1-amines were synthesized in three steps in 62–68% overall yields using apiol extracted from parsley seeds as a starting material. The compounds obtained being structurally similar to neurotropic amphetamines demonstrated in vitro radical scavenging activity in mouse brain lipids and red blood cells together with the lack of embryotoxicity in the sea urchin embryo model. The presence of pyrrolidine or morpholine moieties was beneficial for the antioxidant activity.

Funders

Russian Science Foundation
24-23-00024

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