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Design and biomedical applications of fluorescent probes based on hemicyanine dyes

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10.71267/mencom.7826
Published 2025-11-29
Focus article , Volume 36, Issue 1, 1-11
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Ustimova M. A., Fedorova O. A. Design and biomedical applications of fluorescent probes based on hemicyanine dyes // Mendeleev Communications. 2025. Vol. 36. No. 1. pp. 1-11.
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Ustimova M. A., Fedorova O. A. Design and biomedical applications of fluorescent probes based on hemicyanine dyes // Mendeleev Communications. 2025. Vol. 36. No. 1. pp. 1-11.
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TY - JOUR
DO - 10.71267/mencom.7826
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7826
TI - Design and biomedical applications of fluorescent probes based on hemicyanine dyes
T2 - Mendeleev Communications
AU - Ustimova, M A
AU - Fedorova, Olga Anatol'evna
PY - 2025
DA - 2025/11/29
PB - Mendeleev Communications
SP - 1-11
IS - 1
VL - 36
ER -
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@article{2025_Ustimova,
author = {M A Ustimova and Olga Anatol'evna Fedorova},
title = {Design and biomedical applications of fluorescent probes based on hemicyanine dyes},
journal = {Mendeleev Communications},
year = {2025},
volume = {36},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7826},
number = {1},
pages = {1--11},
doi = {10.71267/mencom.7826}
}
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Ustimova, M. A., and Olga Anatol'evna Fedorova. “Design and biomedical applications of fluorescent probes based on hemicyanine dyes.” Mendeleev Communications, vol. 36, no. 1, Nov. 2025, pp. 1-11. https://mendcomm.colab.ws/publications/10.71267/mencom.7826.
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Keywords

bioimaging
BSA
DNA
endoplasmic reticulum
fluorescent sensor
hemicyanine dyes
HSA.
lysosomes
mitochondria
polymethine dyes
RNA
styryl dyes
β-amyloid

Abstract

In recent years, fluorescence-based methods have been extensively used to analyze biological processes and to develop medical diagnostic systems. Small molecules, primarily dyes, are commonly used as fluorescent reagents. This review focuses on hemicyanine dyes and their application as fluorophores in biomedical research. These compounds exhibit high affinity for biological molecules, which explains their widespread use for staining nucleic acids and cellular organelles such as mitochondria, lysosomes, endoplasmic reticulum, and nuclei. Examples of hemicyanines used for detecting pathological conditions, including mitophagy, β-amyloid aggregation, and others are also provided.

Funders

Russian Science Foundation
21-73-20158-P

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