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Functionalized pyrazine-2-carboxamides in the synthesis of new palladium-based potential cytotoxic agents

Svetlana G Churusova 1
Svetlana G Churusova
, 
Aleksandr V Konovalov 1
Aleksandr V Konovalov
,  , 
Ekaterina Yu Rybalkina 2
Ekaterina Yu Rybalkina
, 
Yulia Vladimirovna Nelyubina 3
Yulia Vladimirovna Nelyubina
, 
Svetlana A Soloveva 4
Svetlana A Soloveva
, 
Aleksandr Sergeevich Peregudov 1
Aleksandr Sergeevich Peregudov
, 
Zinaida Sergeevna Klemenkova 1
Zinaida Sergeevna Klemenkova
, 
Vladimir Andreevich Kozlov 1
Vladimir Andreevich Kozlov
10.71267/mencom.7819
Published 2025-10-21
Communication , Volume 35, Issue 6, 657-660
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Churusova S. G. et al. Functionalized pyrazine-2-carboxamides in the synthesis of new palladium-based potential cytotoxic agents // Mendeleev Communications. 2025. Vol. 35. No. 6. pp. 657-660.
GOST all authors (up to 50) Copy
Churusova S. G., Konovalov A. V., Aleksanyan D. V., Rybalkina E. Yu., Nelyubina Y. V., Soloveva S. A., Peregudov A. S., Klemenkova Z. S., Kozlov V. A. Functionalized pyrazine-2-carboxamides in the synthesis of new palladium-based potential cytotoxic agents // Mendeleev Communications. 2025. Vol. 35. No. 6. pp. 657-660.
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TY - JOUR
DO - 10.71267/mencom.7819
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7819
TI - Functionalized pyrazine-2-carboxamides in the synthesis of new palladium-based potential cytotoxic agents
T2 - Mendeleev Communications
AU - Churusova, Svetlana G
AU - Konovalov, Aleksandr V
AU - Aleksanyan, Diana Vladimirovna
AU - Rybalkina, Ekaterina Yu
AU - Nelyubina, Yulia Vladimirovna
AU - Soloveva, Svetlana A
AU - Peregudov, Aleksandr Sergeevich
AU - Klemenkova, Zinaida Sergeevna
AU - Kozlov, Vladimir Andreevich
PY - 2025
DA - 2025/10/21
PB - Mendeleev Communications
SP - 657-660
IS - 6
VL - 35
ER -
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@article{2025_Churusova,
author = {Svetlana G Churusova and Aleksandr V Konovalov and Diana Vladimirovna Aleksanyan and Ekaterina Yu Rybalkina and Yulia Vladimirovna Nelyubina and Svetlana A Soloveva and Aleksandr Sergeevich Peregudov and Zinaida Sergeevna Klemenkova and Vladimir Andreevich Kozlov},
title = {Functionalized pyrazine-2-carboxamides in the synthesis of new palladium-based potential cytotoxic agents},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7819},
number = {6},
pages = {657--660},
doi = {10.71267/mencom.7819}
}
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Churusova, Svetlana G., et al. “Functionalized pyrazine-2-carboxamides in the synthesis of new palladium-based potential cytotoxic agents.” Mendeleev Communications, vol. 35, no. 6, Oct. 2025, pp. 657-660. https://mendcomm.colab.ws/publications/10.71267/mencom.7819.

Keywords

carboxamides
cyclometalation
metal-based anticancer agents.
palladium
phosphine sulfides
pincer ligands
pyrazines

Abstract

The reactions of α-(aminoalkyl)diphenylphosphine sulfides with pyrazine-2-carbonyl chloride hydrochloride afforded two novel representatives of non-classical amide-based pincer ligands. The latter were shown to furnish PdII complexes with either bi- or tridentate coordination modes of the ligands, depending on the reaction conditions. The cytotoxicity assays revealed remarkable activity of one of the resulting cyclopalladated derivatives, especially, towards hematopoietic cancer cell lines.

Funders

Russian Science Foundation
22-73-10044