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Photocatalytic radical arylation/cyclization of N-arylacrylamides to 3-benzyl oxindoles

Jue Wang 1
Jue Wang
, 
Wenkai Lai 1
Wenkai Lai
, 
Mei Hong 2
Mei Hong
, 
Chengxian Liu 3
Chengxian Liu
, 
Liang Wang 3
Liang Wang
1 Department of Chemical and Material Engineering, Quzhou College of Technology, 324002 Quzhou, P. R. China
2 College of Chemical Engineering, Nanjing Forestry University, 210037 Nanjing, P. R. China
3 School of Chemical and Pharmaceutical Engineering, Changzhou Vocational Institute of Engineering, 213164 Changzhou, P. R. China
10.71267/mencom.7798
Published 2025-10-21
Communication , Volume 35, Issue 6, 717-719
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Wang J. et al. Photocatalytic radical arylation/cyclization of N-arylacrylamides to 3-benzyl oxindoles // Mendeleev Communications. 2025. Vol. 35. No. 6. pp. 717-719.
GOST all authors (up to 50) Copy
Wang J., Lai W., Hong M., Liu C., Wang L. Photocatalytic radical arylation/cyclization of N-arylacrylamides to 3-benzyl oxindoles // Mendeleev Communications. 2025. Vol. 35. No. 6. pp. 717-719.
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TY - JOUR
DO - 10.71267/mencom.7798
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7798
TI - Photocatalytic radical arylation/cyclization of N-arylacrylamides to 3-benzyl oxindoles
T2 - Mendeleev Communications
AU - Wang, Jue
AU - Lai, Wenkai
AU - Hong, Mei
AU - Liu, Chengxian
AU - Wang, Liang
PY - 2025
DA - 2025/10/21
PB - Mendeleev Communications
SP - 717-719
IS - 6
VL - 35
ER -
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@article{2025_Wang,
author = {Jue Wang and Wenkai Lai and Mei Hong and Chengxian Liu and Liang Wang},
title = {Photocatalytic radical arylation/cyclization of N-arylacrylamides to 3-benzyl oxindoles},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7798},
number = {6},
pages = {717--719},
doi = {10.71267/mencom.7798}
}
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Wang, Jue, et al. “Photocatalytic radical arylation/cyclization of N-arylacrylamides to 3-benzyl oxindoles.” Mendeleev Communications, vol. 35, no. 6, Oct. 2025, pp. 717-719. https://mendcomm.colab.ws/publications/10.71267/mencom.7798.

Keywords

arylacrylamides
arylation
diaryliodonium triflate
oxindoles.
photocatalysis
radical cyclization

Abstract

A photocatalytic tandem radical arylation/cyclization of N-arylacrylamides with diaryliodonium triflates at room temperature affords 3-(benzyl)oxindoles in moderate to good yields. The diaryliodonium triflates upon blue visible light irradiation in the presence of Ir(ppy)2(dtbbpy) · PF6 as the photocatalyst release aryl radicals which would add at the double bond of the acrylamide to initiate the cyclization involving the N-aryl substituent.