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Chiral hydrogen-bonded frameworks featuring proline motifs as heterogeneous catalysts for the enantioselective synthesis of warfarin

Ilya S. Aniskin 1
Ilya S. Aniskin
, 
Maxim Alekseevich Shandybo 1, 2
Maxim Alekseevich Shandybo
, 
Svetlana A Kuznetsova 1
Svetlana A Kuznetsova
, 
Klim Olegovich Biriukov 1
Klim Olegovich Biriukov
, 
Mikhail Mikhailovich, Jr Ilyin 1
Mikhail Mikhailovich, Jr Ilyin
, 
Mariam Grigoryevna Ezernitskaya 1
Mariam Grigoryevna Ezernitskaya
, 
Sergey P. Kutumov 1
Sergey P. Kutumov
, 
Artavazd S. Poghosyan 3
Artavazd S. Poghosyan
, 
Ashot S. Saghyan 3
Ashot S. Saghyan
, 
Valerij P. Chernyshev 4
Valerij P. Chernyshev
,  , 
Yurii Nikolaevich Belokon 1
Yurii Nikolaevich Belokon
2 National Research University Higher School of Economics (HSE University), 101000 Moscow, Russian Federation
3 Scientific and Production Center ‘Armbiotechnology’, National Academy of Sciences of Republic Armenia, 0056 Yerevan, Armenia
4 JSC ‘Shchelkovo Agrokhim’, 141101 Shchelkovo, Moscow Region, Russian Federation
10.71267/mencom.7796
Published 2025-10-21
Communication , Volume 35, Issue 6, 642-644
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Aniskin I. S. et al. Chiral hydrogen-bonded frameworks featuring proline motifs as heterogeneous catalysts for the enantioselective synthesis of warfarin // Mendeleev Communications. 2025. Vol. 35. No. 6. pp. 642-644.
GOST all authors (up to 50) Copy
Aniskin I. S., Shandybo M. A., Kuznetsova S. A., Biriukov K. O., Ilyin M. M. J., Ezernitskaya M. G., Kutumov S. P., Poghosyan A. S., Saghyan A. S., Chernyshev V. P., Chusov D. A., Belokon Y. N. Chiral hydrogen-bonded frameworks featuring proline motifs as heterogeneous catalysts for the enantioselective synthesis of warfarin // Mendeleev Communications. 2025. Vol. 35. No. 6. pp. 642-644.
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TY - JOUR
DO - 10.71267/mencom.7796
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7796
TI - Chiral hydrogen-bonded frameworks featuring proline motifs as heterogeneous catalysts for the enantioselective synthesis of warfarin
T2 - Mendeleev Communications
AU - Aniskin, Ilya S.
AU - Shandybo, Maxim Alekseevich
AU - Kuznetsova, Svetlana A
AU - Biriukov, Klim Olegovich
AU - Ilyin, Mikhail Mikhailovich, Jr
AU - Ezernitskaya, Mariam Grigoryevna
AU - Kutumov, Sergey P.
AU - Poghosyan, Artavazd S.
AU - Saghyan, Ashot S.
AU - Chernyshev, Valerij P.
AU - Chusov, Denis Alexandrovich
AU - Belokon, Yurii Nikolaevich
PY - 2025
DA - 2025/10/21
PB - Mendeleev Communications
SP - 642-644
IS - 6
VL - 35
ER -
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@article{2025_Aniskin,
author = {Ilya S. Aniskin and Maxim Alekseevich Shandybo and Svetlana A Kuznetsova and Klim Olegovich Biriukov and Mikhail Mikhailovich, Jr Ilyin and Mariam Grigoryevna Ezernitskaya and Sergey P. Kutumov and Artavazd S. Poghosyan and Ashot S. Saghyan and Valerij P. Chernyshev and Denis Alexandrovich Chusov and Yurii Nikolaevich Belokon},
title = {Chiral hydrogen-bonded frameworks featuring proline motifs as heterogeneous catalysts for the enantioselective synthesis of warfarin},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7796},
number = {6},
pages = {642--644},
doi = {10.71267/mencom.7796}
}
MLA
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Aniskin, Ilya S., et al. “Chiral hydrogen-bonded frameworks featuring proline motifs as heterogeneous catalysts for the enantioselective synthesis of warfarin.” Mendeleev Communications, vol. 35, no. 6, Oct. 2025, pp. 642-644. https://mendcomm.colab.ws/publications/10.71267/mencom.7796.

Keywords

asymmetric catalysis
chiral tetraamines
heterogeneous catalysis
hydrogen-bonded organic frameworks
proline.
warfarin

Abstract

Chiral hydrogen-bonded organic frameworks incorporating proline motifs were synthesized from tetrakis-, bis- or monoprolinamide precursors and di- or tetracarboxylic or sulfonic acids. Their testing as heterogeneous catalysts for the synthesis of warfarin provided product yields of up to

84% with ee values of up to 45%.

Funders

Ministry of Education and Science of the Russian Federation
contract no. 075-00276-25-00