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Synthesis and photophysical properties of a new glycoconjugate based on meso-arylporphyrin

Alexey Yu Usanyov 1
Alexey Yu Usanyov
, 
Sofia M Sukoreva 1
Sofia M Sukoreva
, 
Nadezhda V Prokopova 1
Nadezhda V Prokopova
,  , 
Natalia Yu Karpechenko 3, 4
Natalia Yu Karpechenko
, 
Natal'ya Aleksandrovna Bragina 1
Natal'ya Aleksandrovna Bragina
, 
Kseniya Aleksandrovna Zhdanova 1
Kseniya Aleksandrovna Zhdanova
1 M. V. Lomonosov Institute of Fine Chemical Technologies, MIREA -- Russian Technological University, 119571 Moscow, Russian Federation
2 N. N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russian Federation
4 N. N. Blokhin National Medical Research Center of Oncology, 115522 Moscow, Russian Federation
10.71267/mencom.7791
Published 2025-10-21
Communication , Volume 35, Issue 6, 667-669
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Usanyov A. Yu. et al. Synthesis and photophysical properties of a new glycoconjugate based on meso-arylporphyrin // Mendeleev Communications. 2025. Vol. 35. No. 6. pp. 667-669.
GOST all authors (up to 50) Copy
Usanyov A. Yu., Sukoreva S. M., Prokopova N. V., Gradova M. A., Karpechenko N. Yu., Bragina N. A., Zhdanova K. A. Synthesis and photophysical properties of a new glycoconjugate based on meso-arylporphyrin // Mendeleev Communications. 2025. Vol. 35. No. 6. pp. 667-669.
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TY - JOUR
DO - 10.71267/mencom.7791
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7791
TI - Synthesis and photophysical properties of a new glycoconjugate based on meso-arylporphyrin
T2 - Mendeleev Communications
AU - Usanyov, Alexey Yu
AU - Sukoreva, Sofia M
AU - Prokopova, Nadezhda V
AU - Gradova, Margaret Alekseevna
AU - Karpechenko, Natalia Yu
AU - Bragina, Natal'ya Aleksandrovna
AU - Zhdanova, Kseniya Aleksandrovna
PY - 2025
DA - 2025/10/21
PB - Mendeleev Communications
SP - 667-669
IS - 6
VL - 35
ER -
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@article{2025_Usanyov,
author = {Alexey Yu Usanyov and Sofia M Sukoreva and Nadezhda V Prokopova and Margaret Alekseevna Gradova and Natalia Yu Karpechenko and Natal'ya Aleksandrovna Bragina and Kseniya Aleksandrovna Zhdanova},
title = {Synthesis and photophysical properties of a new glycoconjugate based on meso-arylporphyrin},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7791},
number = {6},
pages = {667--669},
doi = {10.71267/mencom.7791}
}
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Usanyov, Alexey Yu., et al. “Synthesis and photophysical properties of a new glycoconjugate based on meso-arylporphyrin.” Mendeleev Communications, vol. 35, no. 6, Oct. 2025, pp. 667-669. https://mendcomm.colab.ws/publications/10.71267/mencom.7791.

Keywords

2-deoxy-D-glucose
antitumor activity
click reaction
meso-arylporphyrins
photodynamic therapy
photosensitizer.
synthesis

Abstract

New conjugate of meso-aryl-substituted porphyrin and 2-deoxy-D-glucose was synthesized via the Cu-catalyzed azide-alkyne cycloaddition between azido-containing sugar and tetraethynyl-substituted porphyrin. The conjugate exhibits nanomolar photoinduced toxicity, namely, the IC50 for MCF7 cells is 42 nM, and the IC50 dark/IC50 light ratio is 71.

Funders

Russian Science Foundation
22-73-10176