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Rhodium(III)-catalyzed C-H annulation for the construction of antifungal agents based on isocoumarin framework

Vladimir Borisovich Kharitonov 1
Vladimir Borisovich Kharitonov
, 
Olga Gennad'evna Chusova 1
Olga Gennad'evna Chusova
, 
Iolina O Bekshaite 1
Iolina O Bekshaite
, 
Kirill A Vasiliev 1
Kirill A Vasiliev
, 
Aleksei Nikolaevich Rodionov 1
Aleksei Nikolaevich Rodionov
, 
Yulia Vladimirovna Nelyubina 1, 2
Yulia Vladimirovna Nelyubina
, 
Pavel Vladimirovich Dorovatovskii 3
Pavel Vladimirovich Dorovatovskii
, 
Dmitry Alexandrovich Loginov 1
Dmitry Alexandrovich Loginov
10.71267/mencom.7777
Published 2025-07-17
Communication , Volume 35, Issue 5, 602-605
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Kharitonov V. B. et al. Rhodium(III)-catalyzed C-H annulation for the construction of antifungal agents based on isocoumarin framework // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 602-605.
GOST all authors (up to 50) Copy
Kharitonov V. B., Chusova O. G., Bekshaite I. O., Vasiliev K. A., Rodionov A. N., Nelyubina Y. V., Dorovatovskii P. V., Loginov D. A. Rhodium(III)-catalyzed C-H annulation for the construction of antifungal agents based on isocoumarin framework // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 602-605.
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TY - JOUR
DO - 10.71267/mencom.7777
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7777
TI - Rhodium(III)-catalyzed C-H annulation for the construction of antifungal agents based on isocoumarin framework
T2 - Mendeleev Communications
AU - Kharitonov, Vladimir Borisovich
AU - Chusova, Olga Gennad'evna
AU - Bekshaite, Iolina O
AU - Vasiliev, Kirill A
AU - Rodionov, Aleksei Nikolaevich
AU - Nelyubina, Yulia Vladimirovna
AU - Dorovatovskii, Pavel Vladimirovich
AU - Loginov, Dmitry Alexandrovich
PY - 2025
DA - 2025/07/17
PB - Mendeleev Communications
SP - 602-605
IS - 5
VL - 35
ER -
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@article{2025_Kharitonov,
author = {Vladimir Borisovich Kharitonov and Olga Gennad'evna Chusova and Iolina O Bekshaite and Kirill A Vasiliev and Aleksei Nikolaevich Rodionov and Yulia Vladimirovna Nelyubina and Pavel Vladimirovich Dorovatovskii and Dmitry Alexandrovich Loginov},
title = {Rhodium(III)-catalyzed C-H annulation for the construction of antifungal agents based on isocoumarin framework},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7777},
number = {5},
pages = {602--605},
doi = {10.71267/mencom.7777}
}
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Kharitonov, Vladimir Borisovich, et al. “Rhodium(III)-catalyzed C-H annulation for the construction of antifungal agents based on isocoumarin framework.” Mendeleev Communications, vol. 35, no. 5, Jul. 2025, pp. 602-605. https://mendcomm.colab.ws/publications/10.71267/mencom.7777.

Keywords

alkynes
antifungal agents
benzoic acids
C–H activation
C–H annulation
homogeneous catalysis
isocoumarins
rhodium complexes.

Abstract

A series of hydroxy- and alkoxy-substituted isocoumarins were synthesized in one step by the rhodium-catalyzed C-H annulation of benzoic acids with alkynes. 8,9-Diethyl-6H-[1,3]dioxolo[4,5-f]isochromen-6-one and its isoquinolone analog have effectively inhibited the growth of six types of phytopathogenic fungi at 30 mg dm--3 concentration, the activity exceeding that of the commercial Triadimefon.

Funders

Russian Science Foundation
19-73-20212