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Platinum(IV) prodrugs with heavy-atom-free BODIPY in axial position: instant photoactivation, enhanced biosafety and improved phototoxicity

, 
Anastasia Olegovna Zharova 1
Anastasia Olegovna Zharova
, 
Yulia Aleksandrovna Isaeva 2, 3
Yulia Aleksandrovna Isaeva
, 
Mikhail F Vokuev 1
Mikhail F Vokuev
, 
Igor A Rodin 1
Igor A Rodin
,  ,  , 
Elena Kimovna Beloglazkina 1
Elena Kimovna Beloglazkina
, 
Olga Olegovna Krasnovskaya 1
Olga Olegovna Krasnovskaya
2 Institute of Physics, Technology and Information Systems, Moscow Pedagogical State University, 119435 Moscow, Russian Federation
3 I. M. Sechenov First Moscow State Medical University, 119048 Moscow, Russian Federation
10.71267/mencom.7776
Published 2025-07-17
Communication , Volume 35, Issue 5, 595-597
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Spector D. V. et al. Platinum(IV) prodrugs with heavy-atom-free BODIPY in axial position: instant photoactivation, enhanced biosafety and improved phototoxicity // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 595-597.
GOST all authors (up to 50) Copy
Spector D. V., Zharova A. O., Isaeva Y. A., Vokuev M. F., Rodin I. A., Roznyatovsky V. A., Grishin Y. K., Beloglazkina E. K., Krasnovskaya O. O. Platinum(IV) prodrugs with heavy-atom-free BODIPY in axial position: instant photoactivation, enhanced biosafety and improved phototoxicity // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 595-597.
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TY - JOUR
DO - 10.71267/mencom.7776
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7776
TI - Platinum(IV) prodrugs with heavy-atom-free BODIPY in axial position: instant photoactivation, enhanced biosafety and improved phototoxicity
T2 - Mendeleev Communications
AU - Spector, Daniil Victorovich
AU - Zharova, Anastasia Olegovna
AU - Isaeva, Yulia Aleksandrovna
AU - Vokuev, Mikhail F
AU - Rodin, Igor A
AU - Roznyatovsky, Vitaly A
AU - Grishin, Yuri Konstantinovich
AU - Beloglazkina, Elena Kimovna
AU - Krasnovskaya, Olga Olegovna
PY - 2025
DA - 2025/07/17
PB - Mendeleev Communications
SP - 595-597
IS - 5
VL - 35
ER -
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@article{2025_Spector,
author = {Daniil Victorovich Spector and Anastasia Olegovna Zharova and Yulia Aleksandrovna Isaeva and Mikhail F Vokuev and Igor A Rodin and Vitaly A Roznyatovsky and Yuri Konstantinovich Grishin and Elena Kimovna Beloglazkina and Olga Olegovna Krasnovskaya},
title = {Platinum(IV) prodrugs with heavy-atom-free BODIPY in axial position: instant photoactivation, enhanced biosafety and improved phototoxicity},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7776},
number = {5},
pages = {595--597},
doi = {10.71267/mencom.7776}
}
MLA
Cite this
MLA Copy
Spector, Daniil Victorovich, et al. “Platinum(IV) prodrugs with heavy-atom-free BODIPY in axial position: instant photoactivation, enhanced biosafety and improved phototoxicity.” Mendeleev Communications, vol. 35, no. 5, Jul. 2025, pp. 595-597. https://mendcomm.colab.ws/publications/10.71267/mencom.7776.

Keywords

BODIPY
cisplatin
controlled release
CuAAC cycloaddition
heavy-atom-free photosensitizer
photodynamic therapy
phototoxicity
platinum(IV) prodrugs

Abstract

Two new photoactivable PtIV prodrugs bearing heavy-atomfree BODIPY in the axial position and differing in the linker length were prepared using CuAAC cycloaddition. Under 530 nm green light, both prodrugs produce singlet oxygen and are capable of a rapid cisplatin release in the presence of sodium ascorbate. Investigation of antiproliferative activity demonstrated excellent biosafety of these prodrugs, as well as outstanding phototoxicity under 530 nm low-dose green light.

Funders

Russian Science Foundation
24-75-10014

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