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Fullerene C60 conjugated with L- and D-alanine: integration into lipid bilayer and protection of cell membrane against oxidative stress

Vladimir Anatol'evich Volkov 1
Vladimir Anatol'evich Volkov
, 
Mikhail Victorovich Voronkov 1
Mikhail Victorovich Voronkov
, 
Yakov N. Uglov 2
Yakov N. Uglov
, 
Polina K. Gifer 3
Polina K. Gifer
, 
Valentina Semenova Romanova 4
Valentina Semenova Romanova
, 
Vyacheslav Mikhailovich Misin 1
Vyacheslav Mikhailovich Misin
, 
Oleg Viktorovich Batishchev 3
Oleg Viktorovich Batishchev
10.71267/mencom.7774
Published 2025-07-17
Communication , Volume 35, Issue 5, 589-591
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Volkov V. A. et al. Fullerene C60 conjugated with L- and D-alanine: integration into lipid bilayer and protection of cell membrane against oxidative stress // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 589-591.
GOST all authors (up to 50) Copy
Volkov V. A., Voronkov M. V., Uglov Y. N., Gifer P. K., Romanova V. S., Misin V. M., Batishchev O. V. Fullerene C60 conjugated with L- and D-alanine: integration into lipid bilayer and protection of cell membrane against oxidative stress // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 589-591.
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TY - JOUR
DO - 10.71267/mencom.7774
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7774
TI - Fullerene C60 conjugated with L- and D-alanine: integration into lipid bilayer and protection of cell membrane against oxidative stress
T2 - Mendeleev Communications
AU - Volkov, Vladimir Anatol'evich
AU - Voronkov, Mikhail Victorovich
AU - Uglov, Yakov N.
AU - Gifer, Polina K.
AU - Romanova, Valentina Semenova
AU - Misin, Vyacheslav Mikhailovich
AU - Batishchev, Oleg Viktorovich
PY - 2025
DA - 2025/07/17
PB - Mendeleev Communications
SP - 589-591
IS - 5
VL - 35
ER -
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@article{2025_Volkov,
author = {Vladimir Anatol'evich Volkov and Mikhail Victorovich Voronkov and Yakov N. Uglov and Polina K. Gifer and Valentina Semenova Romanova and Vyacheslav Mikhailovich Misin and Oleg Viktorovich Batishchev},
title = {Fullerene C60 conjugated with L- and D-alanine: integration into lipid bilayer and protection of cell membrane against oxidative stress},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7774},
number = {5},
pages = {589--591},
doi = {10.71267/mencom.7774}
}
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Volkov, Vladimir Anatol'evich, et al. “Fullerene C60 conjugated with L- and D-alanine: integration into lipid bilayer and protection of cell membrane against oxidative stress.” Mendeleev Communications, vol. 35, no. 5, Jul. 2025, pp. 589-591. https://mendcomm.colab.ws/publications/10.71267/mencom.7774.

Keywords

AFM
C60
fluorescence
fullerene
hemolysis
lipid peroxidation
membrane fluidity
nanoparticles
pyrene.

Abstract

Using atomic force microscopy and a fluorescent probe, it was demonstrated that nanoparticles of N-(monohydrofullerenyl)alanine enantiomers effectively embedded into lipid membranes, reduce membrane microviscosity and increase membrane fluidity. Even at a concentration of 1 nM, these C60 fullerene derivatives were found to protect human erythrocytes from free radical-induced hemolysis. The particle sizes of the investigated compounds determined by atomic force microscopy are consistent with small-angle X-ray scattering data indicating the presence of stable aggregate configurations showing a two-fold difference between adjacent maxima in the radius distribution.

Funders

Ministry of Education and Science of the Russian Federation
project nos. 125012000470-01