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Triblock P(D,L)LA-PEG-P(D,L)LA copolymer hydrogels with a variable ratio of hydrophilic and hydrophobic blocks

Yulia Sergeevna Fomina 1
Yulia Sergeevna Fomina
, 
Yury Dmitrievich Zagoskin 1
Yury Dmitrievich Zagoskin
, 
Petr Vladimirovich Dmitryakov 1
Petr Vladimirovich Dmitryakov
, 
Artem Vadimovich Bakirov 1, 2
Artem Vadimovich Bakirov
, 
Sergei Nikolaevich Chvalun 1, 2
Sergei Nikolaevich Chvalun
, 
1 National Research Centre ‘Kurchatov Institute’, 123182 Moscow, Russian Federation
10.71267/mencom.7768
Published 2025-07-17
Communication , Volume 35, Issue 5, 583-585
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Fomina Y. S. et al. Triblock P(D,L)LA-PEG-P(D,L)LA copolymer hydrogels with a variable ratio of hydrophilic and hydrophobic blocks // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 583-585.
GOST all authors (up to 50) Copy
Fomina Y. S., Zagoskin Y. D., Dmitryakov P. V., Bakirov A. V., Chvalun S. N., Grigoriev T. E. Triblock P(D,L)LA-PEG-P(D,L)LA copolymer hydrogels with a variable ratio of hydrophilic and hydrophobic blocks // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 583-585.
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TY - JOUR
DO - 10.71267/mencom.7768
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7768
TI - Triblock P(D,L)LA-PEG-P(D,L)LA copolymer hydrogels with a variable ratio of hydrophilic and hydrophobic blocks
T2 - Mendeleev Communications
AU - Fomina, Yulia Sergeevna
AU - Zagoskin, Yury Dmitrievich
AU - Dmitryakov, Petr Vladimirovich
AU - Bakirov, Artem Vadimovich
AU - Chvalun, Sergei Nikolaevich
AU - Grigoriev, Timofey Evgenyevich
PY - 2025
DA - 2025/07/17
PB - Mendeleev Communications
SP - 583-585
IS - 5
VL - 35
ER -
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@article{2025_Fomina,
author = {Yulia Sergeevna Fomina and Yury Dmitrievich Zagoskin and Petr Vladimirovich Dmitryakov and Artem Vadimovich Bakirov and Sergei Nikolaevich Chvalun and Timofey Evgenyevich Grigoriev},
title = {Triblock P(D,L)LA-PEG-P(D,L)LA copolymer hydrogels with a variable ratio of hydrophilic and hydrophobic blocks},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7768},
number = {5},
pages = {583--585},
doi = {10.71267/mencom.7768}
}
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Fomina, Yulia Sergeevna, et al. “Triblock P(D,L)LA-PEG-P(D,L)LA copolymer hydrogels with a variable ratio of hydrophilic and hydrophobic blocks.” Mendeleev Communications, vol. 35, no. 5, Jul. 2025, pp. 583-585. https://mendcomm.colab.ws/publications/10.71267/mencom.7768.

Keywords

amphiphilic block copolymer
hydrogel
polyethylene glycol.
polylactide
SAXS

Abstract

A series of novel hydrogels were prepared via the solvent replacement method, employing triblock copolymers of D,L-lactide and ethylene glycol. These hydrogels demonstrated a prominent capacity to maintain and preserve their structural integrity; the resulting hydrogel materials exhibited a high elastic modulus, ranging from 7 ± 1 to 37 ± 4 kPa, depending on their composition. The network of hard blocks in these hydrogels was found to be well ordered, revealing a long period, detected by small angle X-ray scattering (SAXS); the order parameter value depends on polylactide chain length.

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