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Green multicomponent efficient approach to (aryl)di(hetaryl)methanes bearing barbituric and hydroxypyridone moieties

, 
Yuliya Evgenievna Ryzhkova 1
Yuliya Evgenievna Ryzhkova
, 
Varvara Mikhailovna Kalashnikova 1
Varvara Mikhailovna Kalashnikova
, 
Mikhail Petrovich Egorov 1
Mikhail Petrovich Egorov
10.71267/mencom.7766
Published 2025-07-17
Communication , Volume 35, Issue 5, 515-517
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Elinson M. N. et al. Green multicomponent efficient approach to (aryl)di(hetaryl)methanes bearing barbituric and hydroxypyridone moieties // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 515-517.
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Elinson M. N., Ryzhkova Y. E., Kalashnikova V. M., Egorov M. P. Green multicomponent efficient approach to (aryl)di(hetaryl)methanes bearing barbituric and hydroxypyridone moieties // Mendeleev Communications. 2025. Vol. 35. No. 5. pp. 515-517.
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TY - JOUR
DO - 10.71267/mencom.7766
UR - https://mendcomm.colab.ws/publications/10.71267/mencom.7766
TI - Green multicomponent efficient approach to (aryl)di(hetaryl)methanes bearing barbituric and hydroxypyridone moieties
T2 - Mendeleev Communications
AU - Elinson, Michail Nikolaevich
AU - Ryzhkova, Yuliya Evgenievna
AU - Kalashnikova, Varvara Mikhailovna
AU - Egorov, Mikhail Petrovich
PY - 2025
DA - 2025/07/17
PB - Mendeleev Communications
SP - 515-517
IS - 5
VL - 35
ER -
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@article{2025_Elinson,
author = {Michail Nikolaevich Elinson and Yuliya Evgenievna Ryzhkova and Varvara Mikhailovna Kalashnikova and Mikhail Petrovich Egorov},
title = {Green multicomponent efficient approach to (aryl)di(hetaryl)methanes bearing barbituric and hydroxypyridone moieties},
journal = {Mendeleev Communications},
year = {2025},
volume = {35},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.71267/mencom.7766},
number = {5},
pages = {515--517},
doi = {10.71267/mencom.7766}
}
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Elinson, Michail Nikolaevich, et al. “Green multicomponent efficient approach to (aryl)di(hetaryl)methanes bearing barbituric and hydroxypyridone moieties.” Mendeleev Communications, vol. 35, no. 5, Jul. 2025, pp. 515-517. https://mendcomm.colab.ws/publications/10.71267/mencom.7766.

Keywords

[(aryl)(dihydropyridin-3-yl)methyl]pyrimidines.
4-hydroxy-6-methylpyridin-2(1H)-one
barbituric acids
benzaldehydes
multicomponent reaction
tandem Knoevenagel–Michael reaction

Abstract

The new multicomponent Knoevenagel-Michael reaction between benzaldehydes and two different CH-acids, N,N'-dimethylbarbituric acid and 4-hydroxy-6-methylpyridin-2(1H)-one, proceeds in refluxing ethanol in the presence of TsOH and affords the (aryl)di(hetaryl)methane products, namely, 5-[(aryl)(2-oxo-1,2-dihydropyridin-3-yl)methyl]pyrimidine-2,4(1H,3H)-diones, in 73--94% yields. The products contain two N-heterocyclic pharmacophore moieties and seem promising for biomedical applications.